Multifaceted thermoresponsive poly(N-vinylcaprolactam) coupled with carbon dots for biomedical applications

Thangavelu Kavitha; Jin Oh Kim; Seungwook Jang; Dong Pyo Kim; Inn Kyu Kang; Soo Young Park

doi:10.1016/j.msec.2015.12.070

Multifaceted thermoresponsive poly(N-vinylcaprolactam) coupled with carbon dots for biomedical applications

Thangavelu Kavitha, Jin Oh Kim, Seungwook Jang, Dong Pyo Kim, Inn Kyu Kang, Soo Young Park

Research output: Contribution to journal › Article › peer-review

44 Scopus citations

Abstract

A fluorescent thermoresponsive polymer consisting of poly(N-vinylcaprolactam) (PVCL) coupled with carbon dots (CDs) (PVCL-CDs) was synthesized by reacting a carboxyl-terminated PVCL derivative with CDs via N-hydroxysuccinimide and N-(3-(dimethylamino)propyl)-N-ethylcarbodiimide hydrochloride coupling. The temperature-dependent fluorescence properties of this material were studied for biomedical applications. Fluorescence quenching in PVCL-CDs was observed above the lower critical solution temperature (LCST) due to thermo-induced aggregation of the PVCL chains. This fluorescent thermoresponsive PVCL-CDs showed good biocompatibility and was demonstrated as a thermometer for sensing intracellular temperatures and also as a marker for bioimaging. In addition, PVCL-CDs showed a significant fluorescence turn-on response to proteins above the LCST, which allows for the utilization of this material in biosensors. Thus, PVCL-CDs, with its tuneable size, low cytotoxicity, good photostability, ease of bioconjugation, and resistance to metabolic degradation, is a novel material for biomedical applications.

Original language	English
Pages (from-to)	492-498
Number of pages	7
Journal	Materials Science and Engineering C
Volume	61
DOIs	https://doi.org/10.1016/j.msec.2015.12.070
State	Published - 1 Apr 2016

Keywords

Bio-imaging
Biocompatibility
Carbon dot
Lower critical solution temperature
Thermo-responsive polymer

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10.1016/j.msec.2015.12.070

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title = "Multifaceted thermoresponsive poly(N-vinylcaprolactam) coupled with carbon dots for biomedical applications",

abstract = "A fluorescent thermoresponsive polymer consisting of poly(N-vinylcaprolactam) (PVCL) coupled with carbon dots (CDs) (PVCL-CDs) was synthesized by reacting a carboxyl-terminated PVCL derivative with CDs via N-hydroxysuccinimide and N-(3-(dimethylamino)propyl)-N-ethylcarbodiimide hydrochloride coupling. The temperature-dependent fluorescence properties of this material were studied for biomedical applications. Fluorescence quenching in PVCL-CDs was observed above the lower critical solution temperature (LCST) due to thermo-induced aggregation of the PVCL chains. This fluorescent thermoresponsive PVCL-CDs showed good biocompatibility and was demonstrated as a thermometer for sensing intracellular temperatures and also as a marker for bioimaging. In addition, PVCL-CDs showed a significant fluorescence turn-on response to proteins above the LCST, which allows for the utilization of this material in biosensors. Thus, PVCL-CDs, with its tuneable size, low cytotoxicity, good photostability, ease of bioconjugation, and resistance to metabolic degradation, is a novel material for biomedical applications.",

keywords = "Bio-imaging, Biocompatibility, Carbon dot, Lower critical solution temperature, Thermo-responsive polymer",

author = "Thangavelu Kavitha and Kim, {Jin Oh} and Seungwook Jang and Kim, {Dong Pyo} and Kang, {Inn Kyu} and Park, {Soo Young}",

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doi = "10.1016/j.msec.2015.12.070",

language = "English",

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AU - Kavitha, Thangavelu

AU - Kim, Jin Oh

AU - Jang, Seungwook

AU - Kim, Dong Pyo

AU - Kang, Inn Kyu

AU - Park, Soo Young

PY - 2016/4/1

Y1 - 2016/4/1

N2 - A fluorescent thermoresponsive polymer consisting of poly(N-vinylcaprolactam) (PVCL) coupled with carbon dots (CDs) (PVCL-CDs) was synthesized by reacting a carboxyl-terminated PVCL derivative with CDs via N-hydroxysuccinimide and N-(3-(dimethylamino)propyl)-N-ethylcarbodiimide hydrochloride coupling. The temperature-dependent fluorescence properties of this material were studied for biomedical applications. Fluorescence quenching in PVCL-CDs was observed above the lower critical solution temperature (LCST) due to thermo-induced aggregation of the PVCL chains. This fluorescent thermoresponsive PVCL-CDs showed good biocompatibility and was demonstrated as a thermometer for sensing intracellular temperatures and also as a marker for bioimaging. In addition, PVCL-CDs showed a significant fluorescence turn-on response to proteins above the LCST, which allows for the utilization of this material in biosensors. Thus, PVCL-CDs, with its tuneable size, low cytotoxicity, good photostability, ease of bioconjugation, and resistance to metabolic degradation, is a novel material for biomedical applications.

AB - A fluorescent thermoresponsive polymer consisting of poly(N-vinylcaprolactam) (PVCL) coupled with carbon dots (CDs) (PVCL-CDs) was synthesized by reacting a carboxyl-terminated PVCL derivative with CDs via N-hydroxysuccinimide and N-(3-(dimethylamino)propyl)-N-ethylcarbodiimide hydrochloride coupling. The temperature-dependent fluorescence properties of this material were studied for biomedical applications. Fluorescence quenching in PVCL-CDs was observed above the lower critical solution temperature (LCST) due to thermo-induced aggregation of the PVCL chains. This fluorescent thermoresponsive PVCL-CDs showed good biocompatibility and was demonstrated as a thermometer for sensing intracellular temperatures and also as a marker for bioimaging. In addition, PVCL-CDs showed a significant fluorescence turn-on response to proteins above the LCST, which allows for the utilization of this material in biosensors. Thus, PVCL-CDs, with its tuneable size, low cytotoxicity, good photostability, ease of bioconjugation, and resistance to metabolic degradation, is a novel material for biomedical applications.

KW - Bio-imaging

KW - Biocompatibility

KW - Carbon dot

KW - Lower critical solution temperature

KW - Thermo-responsive polymer

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DO - 10.1016/j.msec.2015.12.070

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ER -

Multifaceted thermoresponsive poly(N-vinylcaprolactam) coupled with carbon dots for biomedical applications

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Keywords

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