Multifocal Inflammatory Leukoencephalopathy: Use of Thallium-201 SPECT and Proton MRS

Yang Ha Hwang; Chung Kyu Suh; Sung Pa Park

doi:10.3346/jkms.2003.18.4.621

Multifocal Inflammatory Leukoencephalopathy: Use of Thallium-201 SPECT and Proton MRS

Yang Ha Hwang, Chung Kyu Suh, Sung Pa Park

Department of Medicine

Kyungpook National University

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

In a patient receiving 5-fluorouracil and levamisole, neurologic deficits suggest the cerebral demyelinating syndrome as a differential diagnosis. The authors report a patient diagnosed as multifocal inflammatory leukoencephalopathy for which thallium-201 (²⁰¹TI) single photon emission computed tomography (SPECT) and proton magnetic resonance spectroscopy (MRS) were employed as noninvasive diagnostic tools. ²⁰¹TI SPECT study was negative and proton MRS showed an increase of choline and lactate and well preserved N-acetylaspartate. These findings support histopathologic findings of multifocal inflammatory leukoencephalopathy revealing demyelination with relative axonal sparing in the patient.

Original language	English
Pages (from-to)	621-624
Number of pages	4
Journal	Journal of Korean Medical Science
Volume	18
Issue number	4
DOIs	https://doi.org/10.3346/jkms.2003.18.4.621
State	Published - Aug 2003

Keywords

Emission Computed
Fluorouracil
Leukoencephalopathy
Levamisole
Magnetic Resonance Spectroscopy
Singl-Photon
Tomography

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10.3346/jkms.2003.18.4.621

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title = "Multifocal Inflammatory Leukoencephalopathy: Use of Thallium-201 SPECT and Proton MRS",

abstract = "In a patient receiving 5-fluorouracil and levamisole, neurologic deficits suggest the cerebral demyelinating syndrome as a differential diagnosis. The authors report a patient diagnosed as multifocal inflammatory leukoencephalopathy for which thallium-201 (201TI) single photon emission computed tomography (SPECT) and proton magnetic resonance spectroscopy (MRS) were employed as noninvasive diagnostic tools. 201TI SPECT study was negative and proton MRS showed an increase of choline and lactate and well preserved N-acetylaspartate. These findings support histopathologic findings of multifocal inflammatory leukoencephalopathy revealing demyelination with relative axonal sparing in the patient.",

keywords = "Emission Computed, Fluorouracil, Leukoencephalopathy, Levamisole, Magnetic Resonance Spectroscopy, Singl-Photon, Tomography",

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year = "2003",

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doi = "10.3346/jkms.2003.18.4.621",

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T2 - Use of Thallium-201 SPECT and Proton MRS

AU - Hwang, Yang Ha

AU - Suh, Chung Kyu

AU - Park, Sung Pa

PY - 2003/8

Y1 - 2003/8

N2 - In a patient receiving 5-fluorouracil and levamisole, neurologic deficits suggest the cerebral demyelinating syndrome as a differential diagnosis. The authors report a patient diagnosed as multifocal inflammatory leukoencephalopathy for which thallium-201 (201TI) single photon emission computed tomography (SPECT) and proton magnetic resonance spectroscopy (MRS) were employed as noninvasive diagnostic tools. 201TI SPECT study was negative and proton MRS showed an increase of choline and lactate and well preserved N-acetylaspartate. These findings support histopathologic findings of multifocal inflammatory leukoencephalopathy revealing demyelination with relative axonal sparing in the patient.

AB - In a patient receiving 5-fluorouracil and levamisole, neurologic deficits suggest the cerebral demyelinating syndrome as a differential diagnosis. The authors report a patient diagnosed as multifocal inflammatory leukoencephalopathy for which thallium-201 (201TI) single photon emission computed tomography (SPECT) and proton magnetic resonance spectroscopy (MRS) were employed as noninvasive diagnostic tools. 201TI SPECT study was negative and proton MRS showed an increase of choline and lactate and well preserved N-acetylaspartate. These findings support histopathologic findings of multifocal inflammatory leukoencephalopathy revealing demyelination with relative axonal sparing in the patient.

KW - Emission Computed

KW - Fluorouracil

KW - Leukoencephalopathy

KW - Levamisole

KW - Magnetic Resonance Spectroscopy

KW - Singl-Photon

KW - Tomography

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AN - SCOPUS:0348049941

SN - 1011-8934

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JO - Journal of Korean Medical Science

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Multifocal Inflammatory Leukoencephalopathy: Use of Thallium-201 SPECT and Proton MRS

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Keywords

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