Mutual Destruction of Deep Lung Tumor Tissues by Nanodrug-Conjugated Stealth Mesenchymal Stem Cells

Sang Woo Kim; Yeon Kyung Lee; Jeong Hee Hong; Jun Young Park; Young Ae Choi; Dong Un Lee; Jungil Choi; Sun Jin Sym; Sang Hyun Kim; Dongwoo Khang

doi:10.1002/advs.201700860

Mutual Destruction of Deep Lung Tumor Tissues by Nanodrug-Conjugated Stealth Mesenchymal Stem Cells

Sang Woo Kim, Yeon Kyung Lee, Jeong Hee Hong, Jun Young Park, Young Ae Choi, Dong Un Lee, Jungil Choi, Sun Jin Sym, Sang Hyun Kim, Dongwoo Khang

Department of Medicine

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Abstract

Lung cancer is a highly malignant tumor, and targeted delivery of anti-cancer drugs to deep lung tumor tissue remains a challenge in drug design. Here, it is demonstrated that bone marrow mesenchymal stem cells armed with nanodrugs are highly targeted and mutually destructive with malignant lung cancer cells and successfully eradicate lung tumors tissues. Using this approach, the current clinical dose of anti-cancer drugs for the treatment of malignant lung tumors can be decreased by more than 100-fold without triggering immunotoxicity.

Original language	English
Article number	1700860
Journal	Advanced Science
Volume	5
Issue number	5
DOIs	https://doi.org/10.1002/advs.201700860
State	Published - May 2018

Keywords

homing abilities
in vivo safety
lung tumors
mesenchymal stem cells
mutual destruction
nanodrug membrane conjugation

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/advs.201700860

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title = "Mutual Destruction of Deep Lung Tumor Tissues by Nanodrug-Conjugated Stealth Mesenchymal Stem Cells",

abstract = "Lung cancer is a highly malignant tumor, and targeted delivery of anti-cancer drugs to deep lung tumor tissue remains a challenge in drug design. Here, it is demonstrated that bone marrow mesenchymal stem cells armed with nanodrugs are highly targeted and mutually destructive with malignant lung cancer cells and successfully eradicate lung tumors tissues. Using this approach, the current clinical dose of anti-cancer drugs for the treatment of malignant lung tumors can be decreased by more than 100-fold without triggering immunotoxicity.",

keywords = "homing abilities, in vivo safety, lung tumors, mesenchymal stem cells, mutual destruction, nanodrug membrane conjugation",

author = "Kim, {Sang Woo} and Lee, {Yeon Kyung} and Hong, {Jeong Hee} and Park, {Jun Young} and Choi, {Young Ae} and Lee, {Dong Un} and Jungil Choi and Sym, {Sun Jin} and Kim, {Sang Hyun} and Dongwoo Khang",

note = "Publisher Copyright: {\textcopyright} 2018 The Authors. Published by WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim",

year = "2018",

month = may,

doi = "10.1002/advs.201700860",

language = "English",

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journal = "Advanced Science",

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AU - Kim, Sang Woo

AU - Lee, Yeon Kyung

AU - Hong, Jeong Hee

AU - Park, Jun Young

AU - Choi, Young Ae

AU - Lee, Dong Un

AU - Choi, Jungil

AU - Sym, Sun Jin

AU - Kim, Sang Hyun

AU - Khang, Dongwoo

PY - 2018/5

Y1 - 2018/5

N2 - Lung cancer is a highly malignant tumor, and targeted delivery of anti-cancer drugs to deep lung tumor tissue remains a challenge in drug design. Here, it is demonstrated that bone marrow mesenchymal stem cells armed with nanodrugs are highly targeted and mutually destructive with malignant lung cancer cells and successfully eradicate lung tumors tissues. Using this approach, the current clinical dose of anti-cancer drugs for the treatment of malignant lung tumors can be decreased by more than 100-fold without triggering immunotoxicity.

AB - Lung cancer is a highly malignant tumor, and targeted delivery of anti-cancer drugs to deep lung tumor tissue remains a challenge in drug design. Here, it is demonstrated that bone marrow mesenchymal stem cells armed with nanodrugs are highly targeted and mutually destructive with malignant lung cancer cells and successfully eradicate lung tumors tissues. Using this approach, the current clinical dose of anti-cancer drugs for the treatment of malignant lung tumors can be decreased by more than 100-fold without triggering immunotoxicity.

KW - homing abilities

KW - in vivo safety

KW - lung tumors

KW - mesenchymal stem cells

KW - mutual destruction

KW - nanodrug membrane conjugation

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JF - Advanced Science

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ER -

Mutual Destruction of Deep Lung Tumor Tissues by Nanodrug-Conjugated Stealth Mesenchymal Stem Cells

Abstract

Keywords

UN SDGs

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