Nanodelivery systems for overcoming limited transportation of therapeutic molecules through the blood-brain barrier

Ki Taek Kim; Han Sol Lee; Jeong Jun Lee; Eui Kyun Park; Bong Seon Lee; Jae Young Lee; Jong Sup Bae

doi:10.4155/fmc-2018-0208

Nanodelivery systems for overcoming limited transportation of therapeutic molecules through the blood-brain barrier

Ki Taek Kim, Han Sol Lee, Jeong Jun Lee, Eui Kyun Park, Bong Seon Lee, Jae Young Lee, Jong Sup Bae

Research output: Contribution to journal › Review article › peer-review

27 Scopus citations

Abstract

Due to the impermeable structure and barrier function of the blood-brain barrier (BBB), the delivery of therapeutic molecules into the CNS is extremely limited. Nanodelivery systems are regarded as the most effective and versatile carriers for the CNS, as they can transport cargo molecules across the BBB via various mechanisms. This review emphasizes the multi-functionalization strategies of nanodelivery systems and combinatorial approaches for the delivery of therapeutic drugs and genes into the CNS. The characteristics and functions of the BBB and underlying mechanisms of molecular translocation across the BBB are also described.

Original language	English
Pages (from-to)	2659-2674
Number of pages	16
Journal	Future Medicinal Chemistry
Volume	10
Issue number	22
DOIs	https://doi.org/10.4155/fmc-2018-0208
State	Published - Nov 2018

Keywords

blood-brain barrier
carbon nanomaterials
central nervous system
combinatorial strategies
dendrimers
inorganic nanoparticles
lipid/polymer-based nanoparticles
multifunctionalization
nanodelivery systems
quantum-dots

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title = "Nanodelivery systems for overcoming limited transportation of therapeutic molecules through the blood-brain barrier",

abstract = "Due to the impermeable structure and barrier function of the blood-brain barrier (BBB), the delivery of therapeutic molecules into the CNS is extremely limited. Nanodelivery systems are regarded as the most effective and versatile carriers for the CNS, as they can transport cargo molecules across the BBB via various mechanisms. This review emphasizes the multi-functionalization strategies of nanodelivery systems and combinatorial approaches for the delivery of therapeutic drugs and genes into the CNS. The characteristics and functions of the BBB and underlying mechanisms of molecular translocation across the BBB are also described.",

keywords = "blood-brain barrier, carbon nanomaterials, central nervous system, combinatorial strategies, dendrimers, inorganic nanoparticles, lipid/polymer-based nanoparticles, multifunctionalization, nanodelivery systems, quantum-dots",

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AU - Kim, Ki Taek

AU - Lee, Han Sol

AU - Lee, Jeong Jun

AU - Park, Eui Kyun

AU - Lee, Bong Seon

AU - Lee, Jae Young

AU - Bae, Jong Sup

PY - 2018/11

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N2 - Due to the impermeable structure and barrier function of the blood-brain barrier (BBB), the delivery of therapeutic molecules into the CNS is extremely limited. Nanodelivery systems are regarded as the most effective and versatile carriers for the CNS, as they can transport cargo molecules across the BBB via various mechanisms. This review emphasizes the multi-functionalization strategies of nanodelivery systems and combinatorial approaches for the delivery of therapeutic drugs and genes into the CNS. The characteristics and functions of the BBB and underlying mechanisms of molecular translocation across the BBB are also described.

AB - Due to the impermeable structure and barrier function of the blood-brain barrier (BBB), the delivery of therapeutic molecules into the CNS is extremely limited. Nanodelivery systems are regarded as the most effective and versatile carriers for the CNS, as they can transport cargo molecules across the BBB via various mechanisms. This review emphasizes the multi-functionalization strategies of nanodelivery systems and combinatorial approaches for the delivery of therapeutic drugs and genes into the CNS. The characteristics and functions of the BBB and underlying mechanisms of molecular translocation across the BBB are also described.

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KW - carbon nanomaterials

KW - central nervous system

KW - combinatorial strategies

KW - dendrimers

KW - inorganic nanoparticles

KW - lipid/polymer-based nanoparticles

KW - multifunctionalization

KW - nanodelivery systems

KW - quantum-dots

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Nanodelivery systems for overcoming limited transportation of therapeutic molecules through the blood-brain barrier

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