Nanodroplet mediated intravascular sonothrombolysis of retracted clots

Leela Goel, Huaiyu Wu, Bohua Zhang, Jinwook Kim, Paul Dayton, Zhen Xu, Xiaoning Jiang

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

4 Scopus citations

Abstract

Current sonothrombolysis techniques have limited efficacy for treating retracted clots. Nanodroplet (ND) mediated sonothrombolysis has the potential to facilitate tPA penetration into the dense fibrin networks of retracted clots via nanodroplet-induced cavitation. Intravascular sonothrombolysis is of interest to improve catheter directed clot treatments and mitigate off-target effects. This paper investigates the feasibility of nanodroplet-mediated sonothrombolysis with tPA to treat retracted clots, in vitro, using a forward-viewing intravascular transducer. The percent mass decrease of the retracted clots (mean ± std) were 4 ± 2%, 20 ± 3%, 23 ± 5%, 38 ± 9% for the control, tPA + US, ND + US, and ND + tPA + US groups, respectively. All of the sonothrombolysis conditions resulted in statistically significantly higher clot lysis compared to the control group (p<0.05). The combined ND + tPA + US treatment significantly outperformed the ND + US condition (p<0.05) and approached significance for the tPA + US group (p = 0.09). In summary, our forward-viewing intravascular transducer was demonstrated, for the first time, for sonothrombolysis in a retracted clot model by combining NDs and tPA.

Original languageEnglish
Title of host publicationIUS 2020 - International Ultrasonics Symposium, Proceedings
PublisherIEEE Computer Society
ISBN (Electronic)9781728154480
DOIs
StatePublished - 7 Sep 2020
Event2020 IEEE International Ultrasonics Symposium, IUS 2020 - Las Vegas, United States
Duration: 7 Sep 202011 Sep 2020

Publication series

NameIEEE International Ultrasonics Symposium, IUS
Volume2020-September
ISSN (Print)1948-5719
ISSN (Electronic)1948-5727

Conference

Conference2020 IEEE International Ultrasonics Symposium, IUS 2020
Country/TerritoryUnited States
CityLas Vegas
Period7/09/2011/09/20

Keywords

  • Clot lysis
  • Intravascular sonothrombolysis
  • Retracted clots
  • Sonothrombolysis

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