Nanomembranes as Protein Mass Spectrometers

Jonghoo Park; Lloyd M. Smith; Maria Arbulu; Thales V.A.G. de Oliveira; Robert H. Blick

doi:10.1002/9783527691005.ch10

Nanomembranes as Protein Mass Spectrometers

Jonghoo Park
, Lloyd M. Smith
, Maria Arbulu
, Thales V.A.G. de Oliveira
, Robert H. Blick

Department of Electrical Engineering

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Abstract

The premise of this chapter is that the protein detectors that currently exist perform poorly for the mass analysis of high-mass proteins. Over the last few years, we have developed the basics for a new type of protein detector, based upon an entirely new principle for protein detection, and show here a robust and high-performance device that will revolutionize the mass analysis of high-molecular-weight proteins. This will have a tremendous impact on biomarker discovery, pharmaceutical drug screening, and possibly virus detection.

Original language	English
Title of host publication	Silicon Nanomembranes
Subtitle of host publication	Fundamental Science and Applications
Publisher	Wiley-VCH Verlag
Pages	257-269
Number of pages	13
ISBN (Electronic)	9783527691005
ISBN (Print)	9783527338313
DOIs	https://doi.org/10.1002/9783527691005.ch10
State	Published - 20 Jun 2016

Keywords

Ion detector
MALDI TOF
Mass spectrometry
NEMS
Phonon
Proteoforms
Proteomic
Silicon nanomembrane

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10.1002/9783527691005.ch10

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abstract = "The premise of this chapter is that the protein detectors that currently exist perform poorly for the mass analysis of high-mass proteins. Over the last few years, we have developed the basics for a new type of protein detector, based upon an entirely new principle for protein detection, and show here a robust and high-performance device that will revolutionize the mass analysis of high-molecular-weight proteins. This will have a tremendous impact on biomarker discovery, pharmaceutical drug screening, and possibly virus detection.",

keywords = "Ion detector, MALDI TOF, Mass spectrometry, NEMS, Phonon, Proteoforms, Proteomic, Silicon nanomembrane",

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doi = "10.1002/9783527691005.ch10",

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T1 - Nanomembranes as Protein Mass Spectrometers

AU - Park, Jonghoo

AU - Smith, Lloyd M.

AU - Arbulu, Maria

AU - de Oliveira, Thales V.A.G.

AU - Blick, Robert H.

PY - 2016/6/20

Y1 - 2016/6/20

N2 - The premise of this chapter is that the protein detectors that currently exist perform poorly for the mass analysis of high-mass proteins. Over the last few years, we have developed the basics for a new type of protein detector, based upon an entirely new principle for protein detection, and show here a robust and high-performance device that will revolutionize the mass analysis of high-molecular-weight proteins. This will have a tremendous impact on biomarker discovery, pharmaceutical drug screening, and possibly virus detection.

AB - The premise of this chapter is that the protein detectors that currently exist perform poorly for the mass analysis of high-mass proteins. Over the last few years, we have developed the basics for a new type of protein detector, based upon an entirely new principle for protein detection, and show here a robust and high-performance device that will revolutionize the mass analysis of high-molecular-weight proteins. This will have a tremendous impact on biomarker discovery, pharmaceutical drug screening, and possibly virus detection.

KW - Ion detector

KW - MALDI TOF

KW - Mass spectrometry

KW - NEMS

KW - Phonon

KW - Proteoforms

KW - Proteomic

KW - Silicon nanomembrane

UR - https://www.scopus.com/pages/publications/85018253466

U2 - 10.1002/9783527691005.ch10

DO - 10.1002/9783527691005.ch10

M3 - Chapter

AN - SCOPUS:85018253466

SN - 9783527338313

SP - 257

EP - 269

BT - Silicon Nanomembranes

PB - Wiley-VCH Verlag

ER -

Nanomembranes as Protein Mass Spectrometers

Abstract

Keywords

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