Nanoparticles of magnetic ferric oxides encapsulated with poly(D,L latide-co-glycolide) and their applications to magnetic resonance imaging contrast agent

Seung Jun Lee; Jong Ryul Jeong; Sung Chul Shin; Jin Chul Kim; Young Hwan Chang; Yong Min Chang; Jong Duk Kim

doi:10.1016/j.jmmm.2003.12.416

Nanoparticles of magnetic ferric oxides encapsulated with poly(D,L latide-co-glycolide) and their applications to magnetic resonance imaging contrast agent

Seung Jun Lee, Jong Ryul Jeong, Sung Chul Shin, Jin Chul Kim, Young Hwan Chang, Yong Min Chang, Jong Duk Kim

Department of Medicine

Research output: Contribution to journal › Article › peer-review

119 Scopus citations

Abstract

Magnetic nanoparticles of Fe₃O₄ encapsulated with Poly(D,L lactide-co-glycolide) (PLGA) were prepared for magnetic resonance imaging (MRI) contrast agent by using an emulsification-diffusion method. In this study, we have investigated the effects of homogenizer and agitator speed on the nanoparticles formation and the magnetic properties of ferrofluid nanoparticles encapsulated with PLGA with varying the ferromagnetic particle size from 10 to 180 nm. We have confirmed that the ferrofluid nanoparticles encapsulated with PLGA could be utilized as an MRI contrast agent from experiments in animal tissue.

Original language	English
Pages (from-to)	2432-2433
Number of pages	2
Journal	Journal of Magnetism and Magnetic Materials
Volume	272-276
Issue number	III
DOIs	https://doi.org/10.1016/j.jmmm.2003.12.416
State	Published - May 2004

Keywords

Emulsification-diffusion method
Magnetic nanoparticles
MRI contast agent
PLGA

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10.1016/j.jmmm.2003.12.416

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title = "Nanoparticles of magnetic ferric oxides encapsulated with poly(D,L latide-co-glycolide) and their applications to magnetic resonance imaging contrast agent",

abstract = "Magnetic nanoparticles of Fe3O4 encapsulated with Poly(D,L lactide-co-glycolide) (PLGA) were prepared for magnetic resonance imaging (MRI) contrast agent by using an emulsification-diffusion method. In this study, we have investigated the effects of homogenizer and agitator speed on the nanoparticles formation and the magnetic properties of ferrofluid nanoparticles encapsulated with PLGA with varying the ferromagnetic particle size from 10 to 180 nm. We have confirmed that the ferrofluid nanoparticles encapsulated with PLGA could be utilized as an MRI contrast agent from experiments in animal tissue.",

keywords = "Emulsification-diffusion method, Magnetic nanoparticles, MRI contast agent, PLGA",

author = "Lee, {Seung Jun} and Jeong, {Jong Ryul} and Shin, {Sung Chul} and Kim, {Jin Chul} and Chang, {Young Hwan} and Chang, {Yong Min} and Kim, {Jong Duk}",

year = "2004",

month = may,

doi = "10.1016/j.jmmm.2003.12.416",

language = "English",

volume = "272-276",

pages = "2432--2433",

journal = "Journal of Magnetism and Magnetic Materials",

issn = "0304-8853",

publisher = "Elsevier B.V.",

number = "III",

}

Nanoparticles of magnetic ferric oxides encapsulated with poly(D,L latide-co-glycolide) and their applications to magnetic resonance imaging contrast agent. / Lee, Seung Jun; Jeong, Jong Ryul; Shin, Sung Chul et al.
In: Journal of Magnetism and Magnetic Materials, Vol. 272-276, No. III, 05.2004, p. 2432-2433.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Nanoparticles of magnetic ferric oxides encapsulated with poly(D,L latide-co-glycolide) and their applications to magnetic resonance imaging contrast agent

AU - Lee, Seung Jun

AU - Jeong, Jong Ryul

AU - Shin, Sung Chul

AU - Kim, Jin Chul

AU - Chang, Young Hwan

AU - Chang, Yong Min

AU - Kim, Jong Duk

PY - 2004/5

Y1 - 2004/5

N2 - Magnetic nanoparticles of Fe3O4 encapsulated with Poly(D,L lactide-co-glycolide) (PLGA) were prepared for magnetic resonance imaging (MRI) contrast agent by using an emulsification-diffusion method. In this study, we have investigated the effects of homogenizer and agitator speed on the nanoparticles formation and the magnetic properties of ferrofluid nanoparticles encapsulated with PLGA with varying the ferromagnetic particle size from 10 to 180 nm. We have confirmed that the ferrofluid nanoparticles encapsulated with PLGA could be utilized as an MRI contrast agent from experiments in animal tissue.

AB - Magnetic nanoparticles of Fe3O4 encapsulated with Poly(D,L lactide-co-glycolide) (PLGA) were prepared for magnetic resonance imaging (MRI) contrast agent by using an emulsification-diffusion method. In this study, we have investigated the effects of homogenizer and agitator speed on the nanoparticles formation and the magnetic properties of ferrofluid nanoparticles encapsulated with PLGA with varying the ferromagnetic particle size from 10 to 180 nm. We have confirmed that the ferrofluid nanoparticles encapsulated with PLGA could be utilized as an MRI contrast agent from experiments in animal tissue.

KW - Emulsification-diffusion method

KW - Magnetic nanoparticles

KW - MRI contast agent

KW - PLGA

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U2 - 10.1016/j.jmmm.2003.12.416

DO - 10.1016/j.jmmm.2003.12.416

M3 - Article

AN - SCOPUS:4444332831

SN - 0304-8853

VL - 272-276

SP - 2432

EP - 2433

JO - Journal of Magnetism and Magnetic Materials

JF - Journal of Magnetism and Magnetic Materials

IS - III

ER -

Nanoparticles of magnetic ferric oxides encapsulated with poly(D,L latide-co-glycolide) and their applications to magnetic resonance imaging contrast agent

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Keywords

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