Negative regulation of neuronal cell differentiation by INHAT subunit SET/TAF-Iβ

Dong Wook Kim; Kee Beom Kim; Ji Young Kim; Kyu Sun Lee; Sang Beom Seo

doi:10.1016/j.bbrc.2010.08.093

Negative regulation of neuronal cell differentiation by INHAT subunit SET/TAF-Iβ

Dong Wook Kim, Kee Beom Kim, Ji Young Kim, Kyu Sun Lee, Sang Beom Seo

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17 Scopus citations

Abstract

Epigenetic modification plays an important role in transcriptional regulation. As a subunit of the INHAT (inhibitor of histone acetyltransferases) complex, SET/TAF-Iβ evidences transcriptional repression activity. In this study, we demonstrate that SET/TAF-Iβ is abundantly expressed in neuronal tissues of Drosophila embryos. It is expressed at high levels prior to and in early stages of neuronal development, and gradually reduced as differentiation proceeds. SET/TAF-Iβ binds to the promoters of a subset of neuronal development markers and negatively regulates the transcription of these genes. The results of this study show that the knockdown of SET/TAF-Iβ by si-RNA induces neuronal cell differentiation, thus implicating SET/TAF-Iβ as a negative regulator of neuronal development.

Original language	English
Pages (from-to)	419-425
Number of pages	7
Journal	Biochemical and Biophysical Research Communications
Volume	400
Issue number	3
DOIs	https://doi.org/10.1016/j.bbrc.2010.08.093
State	Published - Sep 2010

Keywords

INHAT
Neuronal differentiation
Retinoic acid
SET/TAF-Iβ

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10.1016/j.bbrc.2010.08.093

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title = "Negative regulation of neuronal cell differentiation by INHAT subunit SET/TAF-Iβ",

abstract = "Epigenetic modification plays an important role in transcriptional regulation. As a subunit of the INHAT (inhibitor of histone acetyltransferases) complex, SET/TAF-Iβ evidences transcriptional repression activity. In this study, we demonstrate that SET/TAF-Iβ is abundantly expressed in neuronal tissues of Drosophila embryos. It is expressed at high levels prior to and in early stages of neuronal development, and gradually reduced as differentiation proceeds. SET/TAF-Iβ binds to the promoters of a subset of neuronal development markers and negatively regulates the transcription of these genes. The results of this study show that the knockdown of SET/TAF-Iβ by si-RNA induces neuronal cell differentiation, thus implicating SET/TAF-Iβ as a negative regulator of neuronal development.",

keywords = "INHAT, Neuronal differentiation, Retinoic acid, SET/TAF-Iβ",

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AU - Kim, Dong Wook

AU - Kim, Kee Beom

AU - Kim, Ji Young

AU - Lee, Kyu Sun

AU - Seo, Sang Beom

PY - 2010/9

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AB - Epigenetic modification plays an important role in transcriptional regulation. As a subunit of the INHAT (inhibitor of histone acetyltransferases) complex, SET/TAF-Iβ evidences transcriptional repression activity. In this study, we demonstrate that SET/TAF-Iβ is abundantly expressed in neuronal tissues of Drosophila embryos. It is expressed at high levels prior to and in early stages of neuronal development, and gradually reduced as differentiation proceeds. SET/TAF-Iβ binds to the promoters of a subset of neuronal development markers and negatively regulates the transcription of these genes. The results of this study show that the knockdown of SET/TAF-Iβ by si-RNA induces neuronal cell differentiation, thus implicating SET/TAF-Iβ as a negative regulator of neuronal development.

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KW - Neuronal differentiation

KW - Retinoic acid

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Negative regulation of neuronal cell differentiation by INHAT subunit SET/TAF-Iβ

Abstract

Keywords

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