Neolignans from the Fruits of Magnolia obovata Inhibit NO Production and Have Neuroprotective Effects

Kyeong Hwa Seo; Dae Young Lee; Jae Woo Jung; Dong Sung Lee; Youn Chul Kim; Youn Hyung Lee; Nam In Baek

doi:10.1002/hlca.201500101

Neolignans from the Fruits of Magnolia obovata Inhibit NO Production and Have Neuroprotective Effects

Kyeong Hwa Seo, Dae Young Lee, Jae Woo Jung, Dong Sung Lee, Youn Chul Kim, Youn Hyung Lee, Nam In Baek

School of Life Science and Biotechnology

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

One new sesquineolignan, obovatalignan A (1), and one new neolignan, obovatalignan B (2), were isolated from the Magnolia obovata fruits. Their chemical structure, including absolute configuration, was determined based on various spectroscopic methods, such as HR-EI-MS, 1D-NMR (¹H,¹³C, DEPT), 2D-NMR (gCOSY, gHSQC, gHMBC, NOESY), and CD spectroscopy. The compounds were evaluated for protective effects against glutamate-induced oxidative stress in HT22-immortalized hippocampal cells and inhibitory activity against NO production in LPS-induced RAW 264.7 cells. Compounds 1 and 2 exhibited protective effects against glutamate-induced oxidative stress with EC₅₀values of 18.1 ± 1.23 and 7.10 ± 0.78 μm, respectively, as well as inhibitory effects on NO production with IC₅₀values of > 30.0 and 8.22 ± 2.01 μm, respectively.

Original language	English
Pages (from-to)	411-415
Number of pages	5
Journal	Helvetica Chimica Acta
Volume	99
Issue number	6
DOIs	https://doi.org/10.1002/hlca.201500101
State	Published - Jun 2016

Keywords

HT22
Neuroprotection
NO production
Obovatalignan
RAW 264.7

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title = "Neolignans from the Fruits of Magnolia obovata Inhibit NO Production and Have Neuroprotective Effects",

abstract = "One new sesquineolignan, obovatalignan A (1), and one new neolignan, obovatalignan B (2), were isolated from the Magnolia obovata fruits. Their chemical structure, including absolute configuration, was determined based on various spectroscopic methods, such as HR-EI-MS, 1D-NMR (1H,13C, DEPT), 2D-NMR (gCOSY, gHSQC, gHMBC, NOESY), and CD spectroscopy. The compounds were evaluated for protective effects against glutamate-induced oxidative stress in HT22-immortalized hippocampal cells and inhibitory activity against NO production in LPS-induced RAW 264.7 cells. Compounds 1 and 2 exhibited protective effects against glutamate-induced oxidative stress with EC50values of 18.1 ± 1.23 and 7.10 ± 0.78 μm, respectively, as well as inhibitory effects on NO production with IC50values of > 30.0 and 8.22 ± 2.01 μm, respectively.",

keywords = "HT22, Neuroprotection, NO production, Obovatalignan, RAW 264.7",

author = "Seo, {Kyeong Hwa} and Lee, {Dae Young} and Jung, {Jae Woo} and Lee, {Dong Sung} and Kim, {Youn Chul} and Lee, {Youn Hyung} and Baek, {Nam In}",

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year = "2016",

month = jun,

doi = "10.1002/hlca.201500101",

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T1 - Neolignans from the Fruits of Magnolia obovata Inhibit NO Production and Have Neuroprotective Effects

AU - Seo, Kyeong Hwa

AU - Lee, Dae Young

AU - Jung, Jae Woo

AU - Lee, Dong Sung

AU - Kim, Youn Chul

AU - Lee, Youn Hyung

AU - Baek, Nam In

PY - 2016/6

Y1 - 2016/6

N2 - One new sesquineolignan, obovatalignan A (1), and one new neolignan, obovatalignan B (2), were isolated from the Magnolia obovata fruits. Their chemical structure, including absolute configuration, was determined based on various spectroscopic methods, such as HR-EI-MS, 1D-NMR (1H,13C, DEPT), 2D-NMR (gCOSY, gHSQC, gHMBC, NOESY), and CD spectroscopy. The compounds were evaluated for protective effects against glutamate-induced oxidative stress in HT22-immortalized hippocampal cells and inhibitory activity against NO production in LPS-induced RAW 264.7 cells. Compounds 1 and 2 exhibited protective effects against glutamate-induced oxidative stress with EC50values of 18.1 ± 1.23 and 7.10 ± 0.78 μm, respectively, as well as inhibitory effects on NO production with IC50values of > 30.0 and 8.22 ± 2.01 μm, respectively.

AB - One new sesquineolignan, obovatalignan A (1), and one new neolignan, obovatalignan B (2), were isolated from the Magnolia obovata fruits. Their chemical structure, including absolute configuration, was determined based on various spectroscopic methods, such as HR-EI-MS, 1D-NMR (1H,13C, DEPT), 2D-NMR (gCOSY, gHSQC, gHMBC, NOESY), and CD spectroscopy. The compounds were evaluated for protective effects against glutamate-induced oxidative stress in HT22-immortalized hippocampal cells and inhibitory activity against NO production in LPS-induced RAW 264.7 cells. Compounds 1 and 2 exhibited protective effects against glutamate-induced oxidative stress with EC50values of 18.1 ± 1.23 and 7.10 ± 0.78 μm, respectively, as well as inhibitory effects on NO production with IC50values of > 30.0 and 8.22 ± 2.01 μm, respectively.

KW - HT22

KW - Neuroprotection

KW - NO production

KW - Obovatalignan

KW - RAW 264.7

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DO - 10.1002/hlca.201500101

M3 - Article

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SN - 0018-019X

VL - 99

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JO - Helvetica Chimica Acta

JF - Helvetica Chimica Acta

IS - 6

ER -

Neolignans from the Fruits of Magnolia obovata Inhibit NO Production and Have Neuroprotective Effects

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Keywords

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