Neurodegeneration augments the ability of bone marrow-derived mesenchymal stem cells to fuse with Purkinje neurons in Niemann-Pick type C mice

Jae Sung Bae; Shigeki Furuya; Yoko Shinoda; Shogo Endo; Edward H. Schuchman; Yoshio Hirabayashi; Hee Kyung Jin

doi:10.1089/hum.2005.16.1006

Neurodegeneration augments the ability of bone marrow-derived mesenchymal stem cells to fuse with Purkinje neurons in Niemann-Pick type C mice

Jae Sung Bae, Shigeki Furuya, Yoko Shinoda, Shogo Endo, Edward H. Schuchman, Yoshio Hirabayashi, Hee Kyung Jin

Research output: Contribution to journal › Article › peer-review

72 Scopus citations

Abstract

After transplantation, adult bone marrow-derived mesenchymal stem cells (BM-MSCs) may undergo transdifferentiation and/or cell fusion in response to new environments. However, the mechanism(s) that govern these cell fate switches remain unknown. Here we demonstrate that the pathology associated with murine Niemann-Pick disease type C (NP-C) cerebellum augments the ability of BM-MSCs to fuse with Purkinje neurons. The results suggest that the degenerative microenvironment of Purkinje neurons in the NP-C cerebellum modulates the cell fate switch of BM-MSCs via cell fusion.

Original language	English
Pages (from-to)	1006-1011
Number of pages	6
Journal	Human Gene Therapy
Volume	16
Issue number	8
DOIs	https://doi.org/10.1089/hum.2005.16.1006
State	Published - Aug 2005

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10.1089/hum.2005.16.1006

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title = "Neurodegeneration augments the ability of bone marrow-derived mesenchymal stem cells to fuse with Purkinje neurons in Niemann-Pick type C mice",

abstract = "After transplantation, adult bone marrow-derived mesenchymal stem cells (BM-MSCs) may undergo transdifferentiation and/or cell fusion in response to new environments. However, the mechanism(s) that govern these cell fate switches remain unknown. Here we demonstrate that the pathology associated with murine Niemann-Pick disease type C (NP-C) cerebellum augments the ability of BM-MSCs to fuse with Purkinje neurons. The results suggest that the degenerative microenvironment of Purkinje neurons in the NP-C cerebellum modulates the cell fate switch of BM-MSCs via cell fusion.",

author = "Bae, {Jae Sung} and Shigeki Furuya and Yoko Shinoda and Shogo Endo and Schuchman, {Edward H.} and Yoshio Hirabayashi and Jin, {Hee Kyung}",

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AU - Bae, Jae Sung

AU - Furuya, Shigeki

AU - Shinoda, Yoko

AU - Endo, Shogo

AU - Schuchman, Edward H.

AU - Hirabayashi, Yoshio

AU - Jin, Hee Kyung

PY - 2005/8

Y1 - 2005/8

N2 - After transplantation, adult bone marrow-derived mesenchymal stem cells (BM-MSCs) may undergo transdifferentiation and/or cell fusion in response to new environments. However, the mechanism(s) that govern these cell fate switches remain unknown. Here we demonstrate that the pathology associated with murine Niemann-Pick disease type C (NP-C) cerebellum augments the ability of BM-MSCs to fuse with Purkinje neurons. The results suggest that the degenerative microenvironment of Purkinje neurons in the NP-C cerebellum modulates the cell fate switch of BM-MSCs via cell fusion.

AB - After transplantation, adult bone marrow-derived mesenchymal stem cells (BM-MSCs) may undergo transdifferentiation and/or cell fusion in response to new environments. However, the mechanism(s) that govern these cell fate switches remain unknown. Here we demonstrate that the pathology associated with murine Niemann-Pick disease type C (NP-C) cerebellum augments the ability of BM-MSCs to fuse with Purkinje neurons. The results suggest that the degenerative microenvironment of Purkinje neurons in the NP-C cerebellum modulates the cell fate switch of BM-MSCs via cell fusion.

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JO - Human Gene Therapy

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IS - 8

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Neurodegeneration augments the ability of bone marrow-derived mesenchymal stem cells to fuse with Purkinje neurons in Niemann-Pick type C mice

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