Neuroendocrine carcinoma arising in a mediastinal teratoma with pulmonary metastasis: A case report and the chemotherapy response

So Yeon Lee; Young Min Jo; Jaehee Lee; Seung Ick Cha; Tae In Park; Chang Ho Kim

doi:10.2169/internalmedicine.54.3947

Neuroendocrine carcinoma arising in a mediastinal teratoma with pulmonary metastasis: A case report and the chemotherapy response

So Yeon Lee, Young Min Jo, Jaehee Lee, Seung Ick Cha, Tae In Park, Chang Ho Kim

Department of Medicine

Kyungpook National University

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Neuroendocrine carcinoma as a somatic-type malignancy (STM) arising in an extragonadal teratoma is extremely rare. The effect of chemotherapy has been poorly evaluated in such cases contrary to teratomas with other STMs. We herein demonstrate that systemic chemotherapy may be beneficial in a case of neuroendocrine carcinoma arising in a mediastinal teratoma with pulmonary metastasis. A 31-year-old man presented with mediastinal widening visualized on a chest radiograph. Computed tomography showed a huge mediastinal mass with two pulmonary nodules. Surgical resection confirmed the presence of a neuroendocrine carcinoma arising in a mediastinal teratoma and pulmonary metastasis. The patient subsequently received chemotherapy and has had no recurrence during the 28-month follow-up.

Original language	English
Pages (from-to)	1277-1280
Number of pages	4
Journal	Internal Medicine
Volume	54
Issue number	10
DOIs	https://doi.org/10.2169/internalmedicine.54.3947
State	Published - 2015

Keywords

Malignant transformation
Mediastinal teratoma
Neuroendocrine carcinoma

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10.2169/internalmedicine.54.3947

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title = "Neuroendocrine carcinoma arising in a mediastinal teratoma with pulmonary metastasis: A case report and the chemotherapy response",

abstract = "Neuroendocrine carcinoma as a somatic-type malignancy (STM) arising in an extragonadal teratoma is extremely rare. The effect of chemotherapy has been poorly evaluated in such cases contrary to teratomas with other STMs. We herein demonstrate that systemic chemotherapy may be beneficial in a case of neuroendocrine carcinoma arising in a mediastinal teratoma with pulmonary metastasis. A 31-year-old man presented with mediastinal widening visualized on a chest radiograph. Computed tomography showed a huge mediastinal mass with two pulmonary nodules. Surgical resection confirmed the presence of a neuroendocrine carcinoma arising in a mediastinal teratoma and pulmonary metastasis. The patient subsequently received chemotherapy and has had no recurrence during the 28-month follow-up.",

keywords = "Malignant transformation, Mediastinal teratoma, Neuroendocrine carcinoma",

author = "Lee, {So Yeon} and Jo, {Young Min} and Jaehee Lee and Cha, {Seung Ick} and Park, {Tae In} and Kim, {Chang Ho}",

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T1 - Neuroendocrine carcinoma arising in a mediastinal teratoma with pulmonary metastasis

T2 - A case report and the chemotherapy response

AU - Lee, So Yeon

AU - Jo, Young Min

AU - Lee, Jaehee

AU - Cha, Seung Ick

AU - Park, Tae In

AU - Kim, Chang Ho

PY - 2015

Y1 - 2015

N2 - Neuroendocrine carcinoma as a somatic-type malignancy (STM) arising in an extragonadal teratoma is extremely rare. The effect of chemotherapy has been poorly evaluated in such cases contrary to teratomas with other STMs. We herein demonstrate that systemic chemotherapy may be beneficial in a case of neuroendocrine carcinoma arising in a mediastinal teratoma with pulmonary metastasis. A 31-year-old man presented with mediastinal widening visualized on a chest radiograph. Computed tomography showed a huge mediastinal mass with two pulmonary nodules. Surgical resection confirmed the presence of a neuroendocrine carcinoma arising in a mediastinal teratoma and pulmonary metastasis. The patient subsequently received chemotherapy and has had no recurrence during the 28-month follow-up.

AB - Neuroendocrine carcinoma as a somatic-type malignancy (STM) arising in an extragonadal teratoma is extremely rare. The effect of chemotherapy has been poorly evaluated in such cases contrary to teratomas with other STMs. We herein demonstrate that systemic chemotherapy may be beneficial in a case of neuroendocrine carcinoma arising in a mediastinal teratoma with pulmonary metastasis. A 31-year-old man presented with mediastinal widening visualized on a chest radiograph. Computed tomography showed a huge mediastinal mass with two pulmonary nodules. Surgical resection confirmed the presence of a neuroendocrine carcinoma arising in a mediastinal teratoma and pulmonary metastasis. The patient subsequently received chemotherapy and has had no recurrence during the 28-month follow-up.

KW - Malignant transformation

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Neuroendocrine carcinoma arising in a mediastinal teratoma with pulmonary metastasis: A case report and the chemotherapy response

Abstract

Keywords

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