Neuronal ceroid lipofuscinosis in a Border Collie: a case report

Minsu Seo; Yoonhoi Koo; Dongjoon Choi; Sanggu Kim; Taesik Yun; Yeon Chae; Dohee Lee; Hakhyun Kim; Mhan Pyo Yang; Soochong Kim; Byeong Teck Kang

doi:10.14405/kjvr.20220027

Neuronal ceroid lipofuscinosis in a Border Collie: a case report

Minsu Seo
, Yoonhoi Koo
, Dongjoon Choi
, Sanggu Kim
, Taesik Yun
, Yeon Chae
, Dohee Lee
, Hakhyun Kim
, Mhan Pyo Yang
, Soochong Kim
, Byeong Teck Kang

Department of Veterinary Medicine

Chungbuk National University

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

A 2-year-old spayed female Border Collie presented with visual deficits and behavioral changes. Neurological examination revealed bilateral menace response deficit with a normal pupil light reflex. Cerebral cortical thinning, cerebral sulci and cerebellar fissure widening, ventriculomegaly, and cerebral atrophy were observed on magnetic resonance imaging (MRI). Histopathology revealed fluorescent lipopigment accumulation in the cerebrum, and the dog was diagnosed with neuronal ceroid lipofuscinosis. This is the first case report describing the changes in clinical signs, MRI findings, and histopathologic changes in neuronal ceroid lipofuscinosis in Korea.

Original language	English
Article number	e27
Journal	Korean Journal of Veterinary Research
Volume	62
Issue number	4
DOIs	https://doi.org/10.14405/kjvr.20220027
State	Published - 2022

Keywords

aggression
congenital abnormalities
dogs
lysosomal storage diseases
neuronal ceroid-lipofucinoses

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title = "Neuronal ceroid lipofuscinosis in a Border Collie: a case report",

abstract = "A 2-year-old spayed female Border Collie presented with visual deficits and behavioral changes. Neurological examination revealed bilateral menace response deficit with a normal pupil light reflex. Cerebral cortical thinning, cerebral sulci and cerebellar fissure widening, ventriculomegaly, and cerebral atrophy were observed on magnetic resonance imaging (MRI). Histopathology revealed fluorescent lipopigment accumulation in the cerebrum, and the dog was diagnosed with neuronal ceroid lipofuscinosis. This is the first case report describing the changes in clinical signs, MRI findings, and histopathologic changes in neuronal ceroid lipofuscinosis in Korea.",

keywords = "aggression, congenital abnormalities, dogs, lysosomal storage diseases, neuronal ceroid-lipofucinoses",

author = "Minsu Seo and Yoonhoi Koo and Dongjoon Choi and Sanggu Kim and Taesik Yun and Yeon Chae and Dohee Lee and Hakhyun Kim and Yang, \{Mhan Pyo\} and Soochong Kim and Kang, \{Byeong Teck\}",

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year = "2022",

doi = "10.14405/kjvr.20220027",

language = "English",

volume = "62",

journal = "Korean Journal of Veterinary Research",

issn = "2466-1384",

publisher = "Korean Society of Veterinary Science",

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TY - JOUR

T1 - Neuronal ceroid lipofuscinosis in a Border Collie

T2 - a case report

AU - Seo, Minsu

AU - Koo, Yoonhoi

AU - Choi, Dongjoon

AU - Kim, Sanggu

AU - Yun, Taesik

AU - Chae, Yeon

AU - Lee, Dohee

AU - Kim, Hakhyun

AU - Yang, Mhan Pyo

AU - Kim, Soochong

AU - Kang, Byeong Teck

PY - 2022

Y1 - 2022

N2 - A 2-year-old spayed female Border Collie presented with visual deficits and behavioral changes. Neurological examination revealed bilateral menace response deficit with a normal pupil light reflex. Cerebral cortical thinning, cerebral sulci and cerebellar fissure widening, ventriculomegaly, and cerebral atrophy were observed on magnetic resonance imaging (MRI). Histopathology revealed fluorescent lipopigment accumulation in the cerebrum, and the dog was diagnosed with neuronal ceroid lipofuscinosis. This is the first case report describing the changes in clinical signs, MRI findings, and histopathologic changes in neuronal ceroid lipofuscinosis in Korea.

AB - A 2-year-old spayed female Border Collie presented with visual deficits and behavioral changes. Neurological examination revealed bilateral menace response deficit with a normal pupil light reflex. Cerebral cortical thinning, cerebral sulci and cerebellar fissure widening, ventriculomegaly, and cerebral atrophy were observed on magnetic resonance imaging (MRI). Histopathology revealed fluorescent lipopigment accumulation in the cerebrum, and the dog was diagnosed with neuronal ceroid lipofuscinosis. This is the first case report describing the changes in clinical signs, MRI findings, and histopathologic changes in neuronal ceroid lipofuscinosis in Korea.

KW - aggression

KW - congenital abnormalities

KW - dogs

KW - lysosomal storage diseases

KW - neuronal ceroid-lipofucinoses

UR - https://www.scopus.com/pages/publications/85146461925

U2 - 10.14405/kjvr.20220027

DO - 10.14405/kjvr.20220027

M3 - Article

AN - SCOPUS:85146461925

SN - 2466-1384

VL - 62

JO - Korean Journal of Veterinary Research

JF - Korean Journal of Veterinary Research

IS - 4

M1 - e27

ER -

Neuronal ceroid lipofuscinosis in a Border Collie: a case report

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Keywords

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