New anti-glycative flavonoids from Cirsium setidens with potent radical scavenging activities

Gyeong Han Jeong; Eui Kyun Park; Tae Hoon Kim

doi:10.1016/j.phytol.2018.05.029

New anti-glycative flavonoids from Cirsium setidens with potent radical scavenging activities

Gyeong Han Jeong, Eui Kyun Park, Tae Hoon Kim

Department of Dentistry

Daegu University

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Two new methoxylated flavonoids, setidenosides A (1) and B (2), together with three known constituents, linarin (3), 5-O-E-p-coumarolyquinic acid methyl ester (4), and syringin (5), were isolated from a methanol extract of the aerial parts of Cirsium setidens Nakai (Asteraceae) through bioassay-guided fractionation using advanced glycation end products (AGEs) formation assay. The structures of the new compounds were elucidated by spectroscopic and chemical methods Among these isolated compounds, new compounds 1 and 2 showed significant inhibitory effects on AGEs formation with IC₅₀ values of 6.5 ± 0.2 and 9.7 ± 0.3 μM, respectively. In addition, these two new compounds showed significant radical scavenging capacities in an ONOO⁻ scavenging assay.

Original language	English
Pages (from-to)	115-119
Number of pages	5
Journal	Phytochemistry Letters
Volume	26
DOIs	https://doi.org/10.1016/j.phytol.2018.05.029
State	Published - Aug 2018

Keywords

Advanced glycation end products
Asteraceae
Cirsium setidens
Diabetic complications
Monomethoxlyted flavonoids
ONOO scavenging

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.phytol.2018.05.029

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title = "New anti-glycative flavonoids from Cirsium setidens with potent radical scavenging activities",

abstract = "Two new methoxylated flavonoids, setidenosides A (1) and B (2), together with three known constituents, linarin (3), 5-O-E-p-coumarolyquinic acid methyl ester (4), and syringin (5), were isolated from a methanol extract of the aerial parts of Cirsium setidens Nakai (Asteraceae) through bioassay-guided fractionation using advanced glycation end products (AGEs) formation assay. The structures of the new compounds were elucidated by spectroscopic and chemical methods Among these isolated compounds, new compounds 1 and 2 showed significant inhibitory effects on AGEs formation with IC50 values of 6.5 ± 0.2 and 9.7 ± 0.3 μM, respectively. In addition, these two new compounds showed significant radical scavenging capacities in an ONOO− scavenging assay.",

keywords = "Advanced glycation end products, Asteraceae, Cirsium setidens, Diabetic complications, Monomethoxlyted flavonoids, ONOO scavenging",

author = "Jeong, {Gyeong Han} and Park, {Eui Kyun} and Kim, {Tae Hoon}",

note = "Publisher Copyright: {\textcopyright} 2018 Phytochemical Society of Europe",

year = "2018",

month = aug,

doi = "10.1016/j.phytol.2018.05.029",

language = "English",

volume = "26",

pages = "115--119",

journal = "Phytochemistry Letters",

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publisher = "Elsevier Ltd.",

}

TY - JOUR

T1 - New anti-glycative flavonoids from Cirsium setidens with potent radical scavenging activities

AU - Jeong, Gyeong Han

AU - Park, Eui Kyun

AU - Kim, Tae Hoon

PY - 2018/8

Y1 - 2018/8

N2 - Two new methoxylated flavonoids, setidenosides A (1) and B (2), together with three known constituents, linarin (3), 5-O-E-p-coumarolyquinic acid methyl ester (4), and syringin (5), were isolated from a methanol extract of the aerial parts of Cirsium setidens Nakai (Asteraceae) through bioassay-guided fractionation using advanced glycation end products (AGEs) formation assay. The structures of the new compounds were elucidated by spectroscopic and chemical methods Among these isolated compounds, new compounds 1 and 2 showed significant inhibitory effects on AGEs formation with IC50 values of 6.5 ± 0.2 and 9.7 ± 0.3 μM, respectively. In addition, these two new compounds showed significant radical scavenging capacities in an ONOO− scavenging assay.

AB - Two new methoxylated flavonoids, setidenosides A (1) and B (2), together with three known constituents, linarin (3), 5-O-E-p-coumarolyquinic acid methyl ester (4), and syringin (5), were isolated from a methanol extract of the aerial parts of Cirsium setidens Nakai (Asteraceae) through bioassay-guided fractionation using advanced glycation end products (AGEs) formation assay. The structures of the new compounds were elucidated by spectroscopic and chemical methods Among these isolated compounds, new compounds 1 and 2 showed significant inhibitory effects on AGEs formation with IC50 values of 6.5 ± 0.2 and 9.7 ± 0.3 μM, respectively. In addition, these two new compounds showed significant radical scavenging capacities in an ONOO− scavenging assay.

KW - Advanced glycation end products

KW - Asteraceae

KW - Cirsium setidens

KW - Diabetic complications

KW - Monomethoxlyted flavonoids

KW - ONOO scavenging

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U2 - 10.1016/j.phytol.2018.05.029

DO - 10.1016/j.phytol.2018.05.029

M3 - Article

AN - SCOPUS:85047382661

SN - 1874-3900

VL - 26

SP - 115

EP - 119

JO - Phytochemistry Letters

JF - Phytochemistry Letters

ER -

New anti-glycative flavonoids from Cirsium setidens with potent radical scavenging activities

Abstract

Keywords

UN SDGs

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