New anti-glycative flavonoids from Cirsium setidens with potent radical scavenging activities

Gyeong Han Jeong; Eui Kyun Park; Tae Hoon Kim

doi:10.1016/j.phytol.2018.05.029

New anti-glycative flavonoids from Cirsium setidens with potent radical scavenging activities

Gyeong Han Jeong, Eui Kyun Park, Tae Hoon Kim

Department of Dentistry

Daegu University

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Two new methoxylated flavonoids, setidenosides A (1) and B (2), together with three known constituents, linarin (3), 5-O-E-p-coumarolyquinic acid methyl ester (4), and syringin (5), were isolated from a methanol extract of the aerial parts of Cirsium setidens Nakai (Asteraceae) through bioassay-guided fractionation using advanced glycation end products (AGEs) formation assay. The structures of the new compounds were elucidated by spectroscopic and chemical methods Among these isolated compounds, new compounds 1 and 2 showed significant inhibitory effects on AGEs formation with IC₅₀ values of 6.5 ± 0.2 and 9.7 ± 0.3 μM, respectively. In addition, these two new compounds showed significant radical scavenging capacities in an ONOO⁻ scavenging assay.

Original language	English
Pages (from-to)	115-119
Number of pages	5
Journal	Phytochemistry Letters
Volume	26
DOIs	https://doi.org/10.1016/j.phytol.2018.05.029
State	Published - Aug 2018

Keywords

Advanced glycation end products
Asteraceae
Cirsium setidens
Diabetic complications
Monomethoxlyted flavonoids
ONOO scavenging

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.phytol.2018.05.029

Cite this

@article{0c93e9a358b44709b88cf8e93e87d8c7,

title = "New anti-glycative flavonoids from Cirsium setidens with potent radical scavenging activities",

abstract = "Two new methoxylated flavonoids, setidenosides A (1) and B (2), together with three known constituents, linarin (3), 5-O-E-p-coumarolyquinic acid methyl ester (4), and syringin (5), were isolated from a methanol extract of the aerial parts of Cirsium setidens Nakai (Asteraceae) through bioassay-guided fractionation using advanced glycation end products (AGEs) formation assay. The structures of the new compounds were elucidated by spectroscopic and chemical methods Among these isolated compounds, new compounds 1 and 2 showed significant inhibitory effects on AGEs formation with IC50 values of 6.5 ± 0.2 and 9.7 ± 0.3 μM, respectively. In addition, these two new compounds showed significant radical scavenging capacities in an ONOO− scavenging assay.",

keywords = "Advanced glycation end products, Asteraceae, Cirsium setidens, Diabetic complications, Monomethoxlyted flavonoids, ONOO scavenging",

author = "Jeong, \{Gyeong Han\} and Park, \{Eui Kyun\} and Kim, \{Tae Hoon\}",

note = "Publisher Copyright: {\textcopyright} 2018 Phytochemical Society of Europe",

year = "2018",

month = aug,

doi = "10.1016/j.phytol.2018.05.029",

language = "English",

volume = "26",

pages = "115--119",

journal = "Phytochemistry Letters",

issn = "1874-3900",

publisher = "Elsevier Ltd.",

}

TY - JOUR

T1 - New anti-glycative flavonoids from Cirsium setidens with potent radical scavenging activities

AU - Jeong, Gyeong Han

AU - Park, Eui Kyun

AU - Kim, Tae Hoon

PY - 2018/8

Y1 - 2018/8

N2 - Two new methoxylated flavonoids, setidenosides A (1) and B (2), together with three known constituents, linarin (3), 5-O-E-p-coumarolyquinic acid methyl ester (4), and syringin (5), were isolated from a methanol extract of the aerial parts of Cirsium setidens Nakai (Asteraceae) through bioassay-guided fractionation using advanced glycation end products (AGEs) formation assay. The structures of the new compounds were elucidated by spectroscopic and chemical methods Among these isolated compounds, new compounds 1 and 2 showed significant inhibitory effects on AGEs formation with IC50 values of 6.5 ± 0.2 and 9.7 ± 0.3 μM, respectively. In addition, these two new compounds showed significant radical scavenging capacities in an ONOO− scavenging assay.

AB - Two new methoxylated flavonoids, setidenosides A (1) and B (2), together with three known constituents, linarin (3), 5-O-E-p-coumarolyquinic acid methyl ester (4), and syringin (5), were isolated from a methanol extract of the aerial parts of Cirsium setidens Nakai (Asteraceae) through bioassay-guided fractionation using advanced glycation end products (AGEs) formation assay. The structures of the new compounds were elucidated by spectroscopic and chemical methods Among these isolated compounds, new compounds 1 and 2 showed significant inhibitory effects on AGEs formation with IC50 values of 6.5 ± 0.2 and 9.7 ± 0.3 μM, respectively. In addition, these two new compounds showed significant radical scavenging capacities in an ONOO− scavenging assay.

KW - Advanced glycation end products

KW - Asteraceae

KW - Cirsium setidens

KW - Diabetic complications

KW - Monomethoxlyted flavonoids

KW - ONOO scavenging

UR - https://www.scopus.com/pages/publications/85047382661

U2 - 10.1016/j.phytol.2018.05.029

DO - 10.1016/j.phytol.2018.05.029

M3 - Article

AN - SCOPUS:85047382661

SN - 1874-3900

VL - 26

SP - 115

EP - 119

JO - Phytochemistry Letters

JF - Phytochemistry Letters

ER -

New anti-glycative flavonoids from Cirsium setidens with potent radical scavenging activities

Abstract

Keywords

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this