New phenylalkanoids from the rhizome of Cnidium officinalis Makino

Hyoung Geun Kim, Trong Nguyen Nguyen, Yeong Geun Lee, Min Ho Lee, Dae Young Lee, Youn Hyung Lee, Nam In Baek

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2 Scopus citations

Abstract

Cnidium officinalis rhizomes were immersed in 80% MeOH. The extract was fractionated to water, n-butanol, and ethyl acetate fractions (Fr). Open column chromatography was repeatedly carried out on n-butanol and ethyl acetate Fr using silica gel, octadecyl silica gel, and Sephadex LH-20 as the stationary phase affording five phenyl alkanoids 1–5 including two new ones. The molecular structures including stereochemistry were decided based on spectroscopic interpretation of nuclear magnetic resonance, mass spectrometry, and infrared spectroscopy as well as chemical reaction. Three known compounds, coniferyl alcohol methyl ether (1), vanillin (2), and coniferyl aldehyde (3), were reported in the beginning for this plant by authors. Two new phenyl alkanoids were named, 7-methoxyeugenol and cnidiumoside.

Original languageEnglish
Article number79
JournalApplied Biological Chemistry
Volume64
Issue number1
DOIs
StatePublished - Dec 2021

Keywords

  • 7-Methoxyeugenol
  • Cnidium officinalis
  • Cnidiumoside
  • Phenyl alkanoid

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