TY - JOUR
T1 - NF-κB activation and ppar transactivational effects of a new aliphatic acid amide from pericarps of zanthoxylum piperitum
AU - Yang, Seo Young
AU - Tai, Bui Huu
AU - Song, Seok Bean
AU - Li, Wei
AU - Yan, Xi Tao
AU - Sun, Ya Nan
AU - Thao, Nguyen Phuong
AU - Kim, Young Ho
PY - 2014/8/20
Y1 - 2014/8/20
N2 - A new aliphatic acid amide, ZP-amide F (1), and eight known compounds, including bungeanumamide A (2), tumuramide C (3), ZP-amide A (4), ZP-amide B (5), ZP-amide D (6), hyperin (7), quercitrin (8), and (-)- sesamin (9), were isolated from pericarps of Zanthoxylum piperitum. The effects of these compounds on TNFα-induced NF-ΚB activation and transactivational activity of PPARs, including PPARα, PPARβ(Δ) and PPARγ subtypes, were evaluated. Compounds 7 and 9 exhibited potent inhibitory effects on TNFα-induced NF-ΚB activation with IC50 values of 5.50 and 8.10 μM, respectively. Aliphatic acid amide compounds 3, 4 and 6 displayed enhanced effects on PPAR transactivational activity with EC50 values of 47.12, 19.13 and 12.02 μM, respectively. Among them, compound 4 demonstrated an increase in PPARα transactivational activity, compound 3 showed a moderate increase on all PPAR subtypes, whereas compound 6 displayed weak PPAR transactivational activity.
AB - A new aliphatic acid amide, ZP-amide F (1), and eight known compounds, including bungeanumamide A (2), tumuramide C (3), ZP-amide A (4), ZP-amide B (5), ZP-amide D (6), hyperin (7), quercitrin (8), and (-)- sesamin (9), were isolated from pericarps of Zanthoxylum piperitum. The effects of these compounds on TNFα-induced NF-ΚB activation and transactivational activity of PPARs, including PPARα, PPARβ(Δ) and PPARγ subtypes, were evaluated. Compounds 7 and 9 exhibited potent inhibitory effects on TNFα-induced NF-ΚB activation with IC50 values of 5.50 and 8.10 μM, respectively. Aliphatic acid amide compounds 3, 4 and 6 displayed enhanced effects on PPAR transactivational activity with EC50 values of 47.12, 19.13 and 12.02 μM, respectively. Among them, compound 4 demonstrated an increase in PPARα transactivational activity, compound 3 showed a moderate increase on all PPAR subtypes, whereas compound 6 displayed weak PPAR transactivational activity.
KW - Anti-inflammation
KW - NF-κB
KW - Ppar
KW - Zanthoxylum piperitum
KW - ZP-amide F
UR - http://www.scopus.com/inward/record.url?scp=84906348820&partnerID=8YFLogxK
U2 - 10.5012/bkcs.2014.35.8.2361
DO - 10.5012/bkcs.2014.35.8.2361
M3 - Article
AN - SCOPUS:84906348820
SN - 0253-2964
VL - 35
SP - 2361
EP - 2366
JO - Bulletin of the Korean Chemical Society
JF - Bulletin of the Korean Chemical Society
IS - 8
ER -