NF-κB inhibitory activity of compounds isolated from Cantharellus cibarius

Jeong Ah Kim, David Tay, Esperanza Carcache De Blanco

Research output: Contribution to journalArticlepeer-review

21 Scopus citations

Abstract

The inhibitory activities of the extracts of Cantharellus cibarius and isolated compounds were investigated in an enzyme-based ELISA NF-κB assay. Of the tested compounds, ergosterol, ergosterol peroxide and cerevisterol were noted to have the most potent inhibition of NF-κB activation. The ability of the active metabolites to inhibit the NF-κB translocation from the cytoplasm to the nucleus was assessed using a cell-based NF-κB assay. The isolated compounds were elucidated through the analysis of various spectroscopic methods.

Original languageEnglish
Pages (from-to)1104-1106
Number of pages3
JournalPhytotherapy Research
Volume22
Issue number8
DOIs
StatePublished - Aug 2008

Keywords

  • Cantharellus cibarius
  • Cerevisterol
  • Enzyme-based ELISA NF-κB assay
  • Ergosterol
  • Ergosterol peroxide

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