NGL-2 Deletion Leads to Autistic-like Behaviors Responsive to NMDAR Modulation

Seung Min Um; Seungmin Ha; Hyejin Lee; Jihye Kim; Kyungdeok Kim; Wangyong Shin; Yi Sul Cho; Junyeop Daniel Roh; Jaeseung Kang; Taesun Yoo; Young Woo Noh; Yeonsoo Choi; Yong Chul Bae; Eunjoon Kim

doi:10.1016/j.celrep.2018.05.087

NGL-2 Deletion Leads to Autistic-like Behaviors Responsive to NMDAR Modulation

Seung Min Um, Seungmin Ha, Hyejin Lee, Jihye Kim, Kyungdeok Kim, Wangyong Shin, Yi Sul Cho, Junyeop Daniel Roh, Jaeseung Kang, Taesun Yoo, Young Woo Noh, Yeonsoo Choi, Yong Chul Bae, Eunjoon Kim

Department of Dentistry

Research output: Contribution to journal › Article › peer-review

33 Scopus citations

Abstract

NGL-2 is a postsynaptic adhesion molecule known to regulate synaptic transmission, but whether NGL-2 regulates synaptic plasticity and specific behaviors remains unknown. Um et al. find that mice lacking NGL-2 display suppressed NMDA receptor-dependent synaptic plasticity and autistic-like social deficits and repetitive behaviors that are responsive to NMDA receptor activation.

Original language	English
Pages (from-to)	3839-3851
Number of pages	13
Journal	Cell Reports
Volume	23
Issue number	13
DOIs	https://doi.org/10.1016/j.celrep.2018.05.087
State	Published - 26 Jun 2018

Keywords

autism
NMDA receptors
repetitive behavior
social interaction
synaptic adhesion

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10.1016/j.celrep.2018.05.087

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title = "NGL-2 Deletion Leads to Autistic-like Behaviors Responsive to NMDAR Modulation",

abstract = "NGL-2 is a postsynaptic adhesion molecule known to regulate synaptic transmission, but whether NGL-2 regulates synaptic plasticity and specific behaviors remains unknown. Um et al. find that mice lacking NGL-2 display suppressed NMDA receptor-dependent synaptic plasticity and autistic-like social deficits and repetitive behaviors that are responsive to NMDA receptor activation.",

keywords = "autism, NMDA receptors, repetitive behavior, social interaction, synaptic adhesion",

author = "Um, {Seung Min} and Seungmin Ha and Hyejin Lee and Jihye Kim and Kyungdeok Kim and Wangyong Shin and Cho, {Yi Sul} and Roh, {Junyeop Daniel} and Jaeseung Kang and Taesun Yoo and Noh, {Young Woo} and Yeonsoo Choi and Bae, {Yong Chul} and Eunjoon Kim",

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T1 - NGL-2 Deletion Leads to Autistic-like Behaviors Responsive to NMDAR Modulation

AU - Um, Seung Min

AU - Ha, Seungmin

AU - Lee, Hyejin

AU - Kim, Jihye

AU - Kim, Kyungdeok

AU - Shin, Wangyong

AU - Cho, Yi Sul

AU - Roh, Junyeop Daniel

AU - Kang, Jaeseung

AU - Yoo, Taesun

AU - Noh, Young Woo

AU - Choi, Yeonsoo

AU - Bae, Yong Chul

AU - Kim, Eunjoon

PY - 2018/6/26

Y1 - 2018/6/26

N2 - NGL-2 is a postsynaptic adhesion molecule known to regulate synaptic transmission, but whether NGL-2 regulates synaptic plasticity and specific behaviors remains unknown. Um et al. find that mice lacking NGL-2 display suppressed NMDA receptor-dependent synaptic plasticity and autistic-like social deficits and repetitive behaviors that are responsive to NMDA receptor activation.

AB - NGL-2 is a postsynaptic adhesion molecule known to regulate synaptic transmission, but whether NGL-2 regulates synaptic plasticity and specific behaviors remains unknown. Um et al. find that mice lacking NGL-2 display suppressed NMDA receptor-dependent synaptic plasticity and autistic-like social deficits and repetitive behaviors that are responsive to NMDA receptor activation.

KW - autism

KW - NMDA receptors

KW - repetitive behavior

KW - social interaction

KW - synaptic adhesion

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M3 - Article

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EP - 3851

JO - Cell Reports

JF - Cell Reports

IS - 13

ER -

NGL-2 Deletion Leads to Autistic-like Behaviors Responsive to NMDAR Modulation

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Keywords

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