NIR dye-loaded mesoporous silica nanoparticles for a multifunctional theranostic platform: Visualization of tumor and ischemic lesions, and performance of photothermal therapy

Sang Bong Lee; Ho Won Lee; Bobby Aditya Darmawan; In Kyu Lee; Sung Jin Cho; Jungwook Chin; Sang Kyoon Kim; Jong Oh Park; Kil Soo Kim; Sang Woo Lee; Jaetae Lee; Yong Hyun Jeon

doi:10.1016/j.jiec.2020.03.027

NIR dye-loaded mesoporous silica nanoparticles for a multifunctional theranostic platform: Visualization of tumor and ischemic lesions, and performance of photothermal therapy

Sang Bong Lee
, Ho Won Lee
, Bobby Aditya Darmawan
, In Kyu Lee
, Sung Jin Cho
, Jungwook Chin
, Sang Kyoon Kim
, Jong Oh Park
, Kil Soo Kim
, Sang Woo Lee
, Jaetae Lee
, Yong Hyun Jeon

Korea Institute of Medical Microrobotics (KIMIRo)
Chonnam National University
Kyungpook National University
Daegu-Gyeongbuk Medical Innovation Foundation

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

We report the fabrication of multifunctional theranositic biomaterials via non-covalent, rapid, and effective encapsulation of 1,1′dioctadecyl-3,3,3′,3′-tetrametylindotrucarbocyanine iodide (DIR) onto mesoporous silica nanoparticles by coating the surface of polyethylene glycol (PEG-DIR@MSN). PEG-DIR@MSNs exhibited great stability with excellent biocompatibility and photothermal conversion properties. PEG-DIR@MSN allowed for not only the detection of various types of tumor and ischemic lesions but also photothermal therapy against breast cancer in living mice, suggesting that PEG-DIR@MSN is a valuable multifunctional theranostic platform.

Original language	English
Pages (from-to)	99-105
Number of pages	7
Journal	Journal of Industrial and Engineering Chemistry
Volume	88
DOIs	https://doi.org/10.1016/j.jiec.2020.03.027
State	Published - 25 Aug 2020

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Ischemia
Mesoporous silica nanoparticles
Near infrared fluorescent dyes
Photothermal therapy
Theranostic biomaterials
Tumor detection

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10.1016/j.jiec.2020.03.027

Cite this

Lee, S. B., Lee, H. W., Darmawan, B. A., Lee, I. K., Cho, S. J., Chin, J., Kim, S. K., Park, J. O., Kim, K. S., Lee, S. W., Lee, J., & Jeon, Y. H. (2020). NIR dye-loaded mesoporous silica nanoparticles for a multifunctional theranostic platform: Visualization of tumor and ischemic lesions, and performance of photothermal therapy. Journal of Industrial and Engineering Chemistry, 88, 99-105. https://doi.org/10.1016/j.jiec.2020.03.027

@article{dd350bf905ff455989d0cd2eb5551a1e,

title = "NIR dye-loaded mesoporous silica nanoparticles for a multifunctional theranostic platform: Visualization of tumor and ischemic lesions, and performance of photothermal therapy",

abstract = "We report the fabrication of multifunctional theranositic biomaterials via non-covalent, rapid, and effective encapsulation of 1,1′dioctadecyl-3,3,3′,3′-tetrametylindotrucarbocyanine iodide (DIR) onto mesoporous silica nanoparticles by coating the surface of polyethylene glycol (PEG-DIR@MSN). PEG-DIR@MSNs exhibited great stability with excellent biocompatibility and photothermal conversion properties. PEG-DIR@MSN allowed for not only the detection of various types of tumor and ischemic lesions but also photothermal therapy against breast cancer in living mice, suggesting that PEG-DIR@MSN is a valuable multifunctional theranostic platform.",

keywords = "Ischemia, Mesoporous silica nanoparticles, Near infrared fluorescent dyes, Photothermal therapy, Theranostic biomaterials, Tumor detection",

author = "Lee, \{Sang Bong\} and Lee, \{Ho Won\} and Darmawan, \{Bobby Aditya\} and Lee, \{In Kyu\} and Cho, \{Sung Jin\} and Jungwook Chin and Kim, \{Sang Kyoon\} and Park, \{Jong Oh\} and Kim, \{Kil Soo\} and Lee, \{Sang Woo\} and Jaetae Lee and Jeon, \{Yong Hyun\}",

note = "Publisher Copyright: {\textcopyright} 2020 The Korean Society of Industrial and Engineering Chemistry",

year = "2020",

month = aug,

day = "25",

doi = "10.1016/j.jiec.2020.03.027",

language = "English",

volume = "88",

pages = "99--105",

journal = "Journal of Industrial and Engineering Chemistry",

issn = "1226-086X",

publisher = "Korean Society of Industrial Engineering Chemistry",

}

Lee, SB, Lee, HW, Darmawan, BA, Lee, IK, Cho, SJ, Chin, J, Kim, SK, Park, JO, Kim, KS, Lee, SW, Lee, J & Jeon, YH 2020, 'NIR dye-loaded mesoporous silica nanoparticles for a multifunctional theranostic platform: Visualization of tumor and ischemic lesions, and performance of photothermal therapy', Journal of Industrial and Engineering Chemistry, vol. 88, pp. 99-105. https://doi.org/10.1016/j.jiec.2020.03.027

NIR dye-loaded mesoporous silica nanoparticles for a multifunctional theranostic platform: Visualization of tumor and ischemic lesions, and performance of photothermal therapy. / Lee, Sang Bong; Lee, Ho Won; Darmawan, Bobby Aditya et al.
In: Journal of Industrial and Engineering Chemistry, Vol. 88, 25.08.2020, p. 99-105.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - NIR dye-loaded mesoporous silica nanoparticles for a multifunctional theranostic platform

T2 - Visualization of tumor and ischemic lesions, and performance of photothermal therapy

AU - Lee, Sang Bong

AU - Lee, Ho Won

AU - Darmawan, Bobby Aditya

AU - Lee, In Kyu

AU - Cho, Sung Jin

AU - Chin, Jungwook

AU - Kim, Sang Kyoon

AU - Park, Jong Oh

AU - Kim, Kil Soo

AU - Lee, Sang Woo

AU - Lee, Jaetae

AU - Jeon, Yong Hyun

PY - 2020/8/25

Y1 - 2020/8/25

N2 - We report the fabrication of multifunctional theranositic biomaterials via non-covalent, rapid, and effective encapsulation of 1,1′dioctadecyl-3,3,3′,3′-tetrametylindotrucarbocyanine iodide (DIR) onto mesoporous silica nanoparticles by coating the surface of polyethylene glycol (PEG-DIR@MSN). PEG-DIR@MSNs exhibited great stability with excellent biocompatibility and photothermal conversion properties. PEG-DIR@MSN allowed for not only the detection of various types of tumor and ischemic lesions but also photothermal therapy against breast cancer in living mice, suggesting that PEG-DIR@MSN is a valuable multifunctional theranostic platform.

AB - We report the fabrication of multifunctional theranositic biomaterials via non-covalent, rapid, and effective encapsulation of 1,1′dioctadecyl-3,3,3′,3′-tetrametylindotrucarbocyanine iodide (DIR) onto mesoporous silica nanoparticles by coating the surface of polyethylene glycol (PEG-DIR@MSN). PEG-DIR@MSNs exhibited great stability with excellent biocompatibility and photothermal conversion properties. PEG-DIR@MSN allowed for not only the detection of various types of tumor and ischemic lesions but also photothermal therapy against breast cancer in living mice, suggesting that PEG-DIR@MSN is a valuable multifunctional theranostic platform.

KW - Ischemia

KW - Mesoporous silica nanoparticles

KW - Near infrared fluorescent dyes

KW - Photothermal therapy

KW - Theranostic biomaterials

KW - Tumor detection

UR - https://www.scopus.com/pages/publications/85084533934

U2 - 10.1016/j.jiec.2020.03.027

DO - 10.1016/j.jiec.2020.03.027

M3 - Article

AN - SCOPUS:85084533934

SN - 1226-086X

VL - 88

SP - 99

EP - 105

JO - Journal of Industrial and Engineering Chemistry

JF - Journal of Industrial and Engineering Chemistry

ER -

NIR dye-loaded mesoporous silica nanoparticles for a multifunctional theranostic platform: Visualization of tumor and ischemic lesions, and performance of photothermal therapy

Abstract

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Keywords

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