Nisin biosynthesis and its properties

Chan Ick Cheigh; Yu Ryang Pyun

doi:10.1007/s10529-005-2721-x

Nisin biosynthesis and its properties

Chan Ick Cheigh, Yu Ryang Pyun

Department of Food and Food Service Inudstry

Yonsei University

Research output: Contribution to journal › Review article › peer-review

107 Scopus citations

Abstract

The antimicrobial peptide, nisin, produced by several strains of Lactococcus lactis, which belongs to the Class I bacteriocins called lantibiotics, is a small (3.4 kDa), 34-amino acid, cationic, hydrophobic peptide and has the five characteristic (β-methyl)lanthionine rings formed by significant post-translational modification. A cluster of 11 genes has been involved in the biosynthesis of nisin and are proposed to be transcriptionally arranged as nisA(Z)BTCIP, nisRK, and nisFEG. The biosynthesis of nisin is regulated in a growth-phase-dependent manner including nisin-mediated induction which occurs via NisRK two-component regulatory system. This review outlines some of the more recent developments in the properties, regulation and applications of nisin biosynthesis.

Original language	English
Pages (from-to)	1641-1648
Number of pages	8
Journal	Biotechnology Letters
Volume	27
Issue number	21
DOIs	https://doi.org/10.1007/s10529-005-2721-x
State	Published - Nov 2005

Keywords

Nisin
Nisin biosynthesis
Nisin-mediated induction
Regulation
Two-component regulatory system

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10.1007/s10529-005-2721-x

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AB - The antimicrobial peptide, nisin, produced by several strains of Lactococcus lactis, which belongs to the Class I bacteriocins called lantibiotics, is a small (3.4 kDa), 34-amino acid, cationic, hydrophobic peptide and has the five characteristic (β-methyl)lanthionine rings formed by significant post-translational modification. A cluster of 11 genes has been involved in the biosynthesis of nisin and are proposed to be transcriptionally arranged as nisA(Z)BTCIP, nisRK, and nisFEG. The biosynthesis of nisin is regulated in a growth-phase-dependent manner including nisin-mediated induction which occurs via NisRK two-component regulatory system. This review outlines some of the more recent developments in the properties, regulation and applications of nisin biosynthesis.

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Nisin biosynthesis and its properties

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Keywords

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