Nitric Oxide Signaling and Its Association with Ubiquitin‐Mediated Proteasomal Degradation in Plants

Anjali Pande, Bong Gyu Mun, Murtaza Khan, Waqas Rahim, Da Sol Lee, Geun Mo Lee, Tiba Nazar Ibrahim Al Azawi, Adil Hussain, Byung Wook Yun

Research output: Contribution to journalReview articlepeer-review

15 Scopus citations

Abstract

Nitric oxide (NO) is a versatile signaling molecule with diverse roles in plant biology. The NO‐mediated signaling mechanism includes post‐translational modifications (PTMs) of target pro-teins. There exists a close link between NO‐mediated PTMs and the proteasomal degradation of proteins via ubiquitylation. In some cases, ubiquitin‐mediated proteasomal degradation of target proteins is followed by an NO‐mediated post‐translational modification on them, while in other cases NO‐mediated PTMs can regulate the ubiquitylation of the components of ubiquitin‐mediated proteasomal machinery for promoting their activity. Another pathway that links NO signaling with the ubiquitin‐mediated degradation of proteins is the N‐degron pathway. Overall, these mechanisms reflect an important mechanism of NO signal perception and transduction that reflect a close association of NO signaling with proteasomal degradation via ubiquitylation. Therefore, this review provides insight into those pathways that link NO‐PTMs with ubiquitylation.

Original languageEnglish
Article number1657
JournalInternational Journal of Molecular Sciences
Volume23
Issue number3
DOIs
StatePublished - 1 Feb 2022

Keywords

  • Nitric oxide
  • Proteasome
  • Proteolysis
  • S‐nitrosylation
  • Ubiquitylation

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