Abstract
Nitric oxide (NO) is a versatile signaling molecule with diverse roles in plant biology. The NO‐mediated signaling mechanism includes post‐translational modifications (PTMs) of target pro-teins. There exists a close link between NO‐mediated PTMs and the proteasomal degradation of proteins via ubiquitylation. In some cases, ubiquitin‐mediated proteasomal degradation of target proteins is followed by an NO‐mediated post‐translational modification on them, while in other cases NO‐mediated PTMs can regulate the ubiquitylation of the components of ubiquitin‐mediated proteasomal machinery for promoting their activity. Another pathway that links NO signaling with the ubiquitin‐mediated degradation of proteins is the N‐degron pathway. Overall, these mechanisms reflect an important mechanism of NO signal perception and transduction that reflect a close association of NO signaling with proteasomal degradation via ubiquitylation. Therefore, this review provides insight into those pathways that link NO‐PTMs with ubiquitylation.
Original language | English |
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Article number | 1657 |
Journal | International Journal of Molecular Sciences |
Volume | 23 |
Issue number | 3 |
DOIs | |
State | Published - 1 Feb 2022 |
Keywords
- Nitric oxide
- Proteasome
- Proteolysis
- S‐nitrosylation
- Ubiquitylation