Non-biofouling polymeric thin films on solid substrates

Nanoarchitectured polymer thin films are playing an increasingly pivotal role in a wide range of areas such as interfacial reactions, biomedical devices/implants, biosensors, food packing, and marine equipment. This review highlights recent research results in the field of the non-biofouling polymer films, including current understanding of the mechanisms of non-biofouling efficacy against bioentities (for example, proteins, cells, and bacteria) under different biological conditions. We also discuss current advances in the fabrication of non-biofouling coatings and micropatterns of cells on solid substrates and suggest a guideline when designing a non-biofouling polymer films, according to application requirements.