Non-Invasive HbA1c Measurement Using Two-Wavelength Raman Scattering

Jooran Yang, Hyungpyo Kim

Research output: Contribution to journalArticlepeer-review

Abstract

The purpose of this study is to classify the concentration of HbA1c (glycosylated hemoglobin), which is an indicator in the management of accurate blood glucose level in diabetic patients, using a non-invasive optical property measurement method. To measure the optical properties of HbA1c, the optical source uses LEDs and laser diodes of 400 nm in the visible region and 1450 nm in the nearinfrared region using thermopile to detect the Raman scattering intensity. An HbA1c control solution was used. As a result, the optical properties of 5% (normal) and 9% (abnormal) HbA1c control solutions showed specificity in which the output values were reversed at 850 nm and 950 nm, respectively. This property was applied to distinguish between normal and abnormal values in diabetes. In addition, considering tissue penetration depths for non-invasive measurements, two wavelengths were determined to be effective in distinguishing the concentrations of HbA1c control solutions at 5%, 7%, and 9%.

Original languageEnglish
Pages (from-to)305-310
Number of pages6
JournalJournal of Sensor Science and Technology
Volume28
Issue number5
DOIs
StatePublished - Sep 2019

Keywords

  • Diabetes
  • HbA1c
  • Infrared radiation
  • NIR (nearinfrared)
  • Noninvasive
  • Optical properties
  • Thermopile
  • Two-wavelength Raman scattering

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