Nothofagin suppresses mast cell-mediated allergic inflammation

Byeong Cheol Kang, Min Jong Kim, Soyoung Lee, Young Ae Choi, Pil Hoon Park, Tae Yong Shin, Taeg Kyu Kwon, Dongwoo Khang, Sang Hyun Kim

Research output: Contribution to journalArticlepeer-review

20 Scopus citations

Abstract

Mast cells play a major role in immunoglobulin E-mediated allergic inflammation, which is involved in asthma, atopic dermatitis, and allergic rhinitis. Nothofagin has been shown to ameliorate various inflammatory responses such as the septic response and vascular inflammation. In this study, we assessed the inhibitory effect of nothofagin on allergic inflammation using cultured/isolated mast cells and an anaphylaxis mouse model. Nothofagin treatment prevented histamine and β-hexosaminidase release by reducing the influx of calcium into the cytosol in a concentration-dependent manner. Nothofagin also inhibited the gene expression and secretion of pro-inflammatory cytokines such as tumor necrosis factor-α and interleukin-4 by downregulating the phosphorylation of Lyn, Syk, Akt and nuclear translocation of nuclear factor-κB. To confirm these effects of nothofagin in vivo, we used a passive cutaneous anaphylaxis mouse model. Topical administration of nothofagin suppressed local pigmentation and ear thickness. Taken together, these results suggest nothofagin as a potential candidate for the treatment of mast cell-involved allergic inflammatory diseases.

Original languageEnglish
Pages (from-to)1-7
Number of pages7
JournalChemico-Biological Interactions
Volume298
DOIs
StatePublished - 25 Jan 2019

Keywords

  • Allergic inflammation
  • Histamine
  • Mast cells
  • Nothofagin

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