Novel human umbilical vein endothelial cells (HUVEC)-apoptosis inhibitory phytosterol analogues: Insight into their structure-activity relationships

Sujin Lee; Sony Marharjan; Jong Wha Jung; Nam Jung Kim; Kyeojin Kim; Young Taek Han; Changjin Lim; Hyun Jung Choi; Young Geun Kwon; Young Ger Suh

doi:10.1007/s12272-012-0308-3

Novel human umbilical vein endothelial cells (HUVEC)-apoptosis inhibitory phytosterol analogues: Insight into their structure-activity relationships

Sujin Lee, Sony Marharjan, Jong Wha Jung, Nam Jung Kim, Kyeojin Kim, Young Taek Han, Changjin Lim, Hyun Jung Choi, Young Geun Kwon, Young Ger Suh

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Design, synthesis and insight into the structure-activity relationships (SAR) of phytosterol analogues as novel antiapoptotic agents are described. In particular, the non-branched alkyl chain at C24 and the pseudosugar moiety at C3 hydroxyl group turned out crucial for the inhibition of human umbilical vein endothelial cells (HUVEC) apoptosis.

Original language	English
Pages (from-to)	455-460
Number of pages	6
Journal	Archives of Pharmacal Research
Volume	35
Issue number	3
DOIs	https://doi.org/10.1007/s12272-012-0308-3
State	Published - Mar 2012

Keywords

Antiapoptotic agent
HUVEC
Phytosterol

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10.1007/s12272-012-0308-3

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title = "Novel human umbilical vein endothelial cells (HUVEC)-apoptosis inhibitory phytosterol analogues: Insight into their structure-activity relationships",

abstract = "Design, synthesis and insight into the structure-activity relationships (SAR) of phytosterol analogues as novel antiapoptotic agents are described. In particular, the non-branched alkyl chain at C24 and the pseudosugar moiety at C3 hydroxyl group turned out crucial for the inhibition of human umbilical vein endothelial cells (HUVEC) apoptosis.",

keywords = "Antiapoptotic agent, HUVEC, Phytosterol",

author = "Sujin Lee and Sony Marharjan and Jung, {Jong Wha} and Kim, {Nam Jung} and Kyeojin Kim and Han, {Young Taek} and Changjin Lim and Choi, {Hyun Jung} and Kwon, {Young Geun} and Suh, {Young Ger}",

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T1 - Novel human umbilical vein endothelial cells (HUVEC)-apoptosis inhibitory phytosterol analogues

T2 - Insight into their structure-activity relationships

AU - Lee, Sujin

AU - Marharjan, Sony

AU - Jung, Jong Wha

AU - Kim, Nam Jung

AU - Kim, Kyeojin

AU - Han, Young Taek

AU - Lim, Changjin

AU - Choi, Hyun Jung

AU - Kwon, Young Geun

AU - Suh, Young Ger

PY - 2012/3

Y1 - 2012/3

N2 - Design, synthesis and insight into the structure-activity relationships (SAR) of phytosterol analogues as novel antiapoptotic agents are described. In particular, the non-branched alkyl chain at C24 and the pseudosugar moiety at C3 hydroxyl group turned out crucial for the inhibition of human umbilical vein endothelial cells (HUVEC) apoptosis.

AB - Design, synthesis and insight into the structure-activity relationships (SAR) of phytosterol analogues as novel antiapoptotic agents are described. In particular, the non-branched alkyl chain at C24 and the pseudosugar moiety at C3 hydroxyl group turned out crucial for the inhibition of human umbilical vein endothelial cells (HUVEC) apoptosis.

KW - Antiapoptotic agent

KW - HUVEC

KW - Phytosterol

UR - http://www.scopus.com/inward/record.url?scp=84862853457&partnerID=8YFLogxK

U2 - 10.1007/s12272-012-0308-3

DO - 10.1007/s12272-012-0308-3

M3 - Article

C2 - 22477192

AN - SCOPUS:84862853457

SN - 0253-6269

VL - 35

SP - 455

EP - 460

JO - Archives of Pharmacal Research

JF - Archives of Pharmacal Research

IS - 3

ER -

Novel human umbilical vein endothelial cells (HUVEC)-apoptosis inhibitory phytosterol analogues: Insight into their structure-activity relationships

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Keywords

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