Abstract
The development of novel biomaterials and its practical applications have been the subject of much research in the field of scaffolds for regenerative medicine. Classical paradigms in this discipline have demonstrated the success of producing scaffold biomaterials that facilitate tissue growth and provide structural support for cells and the delivery of bioactive molecules. The next challenge is in engineering biomaterials with innovative designs, offering smart and special functionalities which fulfill the optimum requirements for cell growth and tissue regeneration. This chapter aims to review one of such frontier efforts, particularly in the development of novel microspheres having smart capability in the controlled release of oxygen for efficient tissue engineering. Highlights will be on the current status of such development, the state of the art in fabricating oxygen-producing microspheres, in lab evaluation protocols, and its possible integration into tissue engineering applications. The discussion is based on real practice involving related technology and methodology for developing oxygen-releasing microspheres (ORMs) via encapsulating hydrogen peroxide in poly(lactide-co-glycolide) (PLGA) microspheres.
| Original language | English |
|---|---|
| Title of host publication | Handbook of Intelligent Scaffolds for Tissue Engineering and Regenerative Medicine |
| Publisher | Pan Stanford Publishing Pte. Ltd. |
| Pages | 633-664 |
| Number of pages | 32 |
| ISBN (Print) | 9789814267854 |
| DOIs | |
| State | Published - 31 Jan 2012 |