Novel peptides derived from neuropeptide Y prevent chemotherapy-induced bone marrow damage by regulating hematopoietic stem cell microenvironment

Min Hee Park, Bosung Baek, Hee Kyung Jin, Jae sung Bae

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Chemotherapy-induced bone marrow damage is accompanied by acute nerve injury in the bone marrow (BM), resulting in sensory and autonomic neuropathy. Cisplatin, a popular chemotherapy drugs, induces the impairment of hematopoietic stem cells (HSCs) and bone marrow regeneration, leading to chronic bone marrow abnormalities. Previously, we reported the protective roles of neuropeptide Y (NPY) against cisplatin-induced bone marrow impairment. In this study, we identified novel peptides, generated from full-length NPY that rescued cisplatin-induced sensory neuropathy and HSC suppression by regulating cell survival in the BM microenvironment. One of these peptides, especially, showed a better protective property against these impairments compared to that seen in full-length NPY. Therefore, we suggest the NPY sequences most effective against the chemotherapy-induced bone marrow dysfunction that could be potentially useful as therapeutic agents for patients receiving chemotherapy.

Original languageEnglish
Pages (from-to)281-288
Number of pages8
JournalAnimal Cells and Systems
Volume22
Issue number5
DOIs
StatePublished - 3 Sep 2018

Keywords

  • Bone marrow damage
  • bone marrow microenvironment cells
  • Chemotherapy
  • hematopoietic stem cell
  • neuropeptide Y-derived recombinant peptides

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