Novel quinoline-based fluorescent bioimaging probe, KSNP117, for sentinel lymph node mapping

Ahmed A. Elbatrawy; Da Sol Lee; Sang Bong Lee; Hui Jeon Jeon; Sijoon Lee; Kyung Ku Kang; Soo Eun Sung; Ye Ri Han; Sung Jin Cho; Dong Su Kim; Kil Soo Kim; Ghilsoo Nam; Yong Hyun Jeon

doi:10.1039/d1tb00568e

Novel quinoline-based fluorescent bioimaging probe, KSNP117, for sentinel lymph node mapping

Ahmed A. Elbatrawy, Da Sol Lee, Sang Bong Lee, Hui Jeon Jeon, Sijoon Lee, Kyung Ku Kang, Soo Eun Sung, Ye Ri Han, Sung Jin Cho, Dong Su Kim, Kil Soo Kim, Ghilsoo Nam, Yong Hyun Jeon

Department of Veterinary Medicine

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Fluorescent imaging agents with biocompatibility and high sensitivity are urgently required for the accurate detection of sentinel lymph nodes (SLNs). Herein, we report the design of a novel quinoline-based fluorescent probe, designated KSNP117, which can be applied as a biomedical imaging agent in the sensitive and quantitative detection of SLNs. KSNP117 exerted no adverse effects on the proliferation of ovary and immune cells and also showed excellent serum stability with photo-brightening effects.In vivofluorescent imaging revealed the accumulation of KSNP117 in the SLNs of nude mice within 10 min post injection, withoutin vivotoxicity, which was consistent with the findings ofex vivoimaging. These results support the potential of KSNP117 as a promising lymphatic tracer for biomedical imaging applications.

Original language	English
Pages (from-to)	4857-4862
Number of pages	6
Journal	Journal of Materials Chemistry B
Volume	9
Issue number	24
DOIs	https://doi.org/10.1039/d1tb00568e
State	Published - 28 Jun 2021

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title = "Novel quinoline-based fluorescent bioimaging probe, KSNP117, for sentinel lymph node mapping",

abstract = "Fluorescent imaging agents with biocompatibility and high sensitivity are urgently required for the accurate detection of sentinel lymph nodes (SLNs). Herein, we report the design of a novel quinoline-based fluorescent probe, designated KSNP117, which can be applied as a biomedical imaging agent in the sensitive and quantitative detection of SLNs. KSNP117 exerted no adverse effects on the proliferation of ovary and immune cells and also showed excellent serum stability with photo-brightening effects.In vivofluorescent imaging revealed the accumulation of KSNP117 in the SLNs of nude mice within 10 min post injection, withoutin vivotoxicity, which was consistent with the findings ofex vivoimaging. These results support the potential of KSNP117 as a promising lymphatic tracer for biomedical imaging applications.",

author = "Elbatrawy, {Ahmed A.} and Lee, {Da Sol} and Lee, {Sang Bong} and Jeon, {Hui Jeon} and Sijoon Lee and Kang, {Kyung Ku} and Sung, {Soo Eun} and Han, {Ye Ri} and Cho, {Sung Jin} and Kim, {Dong Su} and Kim, {Kil Soo} and Ghilsoo Nam and Jeon, {Yong Hyun}",

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year = "2021",

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doi = "10.1039/d1tb00568e",

language = "English",

volume = "9",

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journal = "Journal of Materials Chemistry B",

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T1 - Novel quinoline-based fluorescent bioimaging probe, KSNP117, for sentinel lymph node mapping

AU - Elbatrawy, Ahmed A.

AU - Lee, Da Sol

AU - Lee, Sang Bong

AU - Jeon, Hui Jeon

AU - Lee, Sijoon

AU - Kang, Kyung Ku

AU - Sung, Soo Eun

AU - Han, Ye Ri

AU - Cho, Sung Jin

AU - Kim, Dong Su

AU - Kim, Kil Soo

AU - Nam, Ghilsoo

AU - Jeon, Yong Hyun

PY - 2021/6/28

Y1 - 2021/6/28

N2 - Fluorescent imaging agents with biocompatibility and high sensitivity are urgently required for the accurate detection of sentinel lymph nodes (SLNs). Herein, we report the design of a novel quinoline-based fluorescent probe, designated KSNP117, which can be applied as a biomedical imaging agent in the sensitive and quantitative detection of SLNs. KSNP117 exerted no adverse effects on the proliferation of ovary and immune cells and also showed excellent serum stability with photo-brightening effects.In vivofluorescent imaging revealed the accumulation of KSNP117 in the SLNs of nude mice within 10 min post injection, withoutin vivotoxicity, which was consistent with the findings ofex vivoimaging. These results support the potential of KSNP117 as a promising lymphatic tracer for biomedical imaging applications.

AB - Fluorescent imaging agents with biocompatibility and high sensitivity are urgently required for the accurate detection of sentinel lymph nodes (SLNs). Herein, we report the design of a novel quinoline-based fluorescent probe, designated KSNP117, which can be applied as a biomedical imaging agent in the sensitive and quantitative detection of SLNs. KSNP117 exerted no adverse effects on the proliferation of ovary and immune cells and also showed excellent serum stability with photo-brightening effects.In vivofluorescent imaging revealed the accumulation of KSNP117 in the SLNs of nude mice within 10 min post injection, withoutin vivotoxicity, which was consistent with the findings ofex vivoimaging. These results support the potential of KSNP117 as a promising lymphatic tracer for biomedical imaging applications.

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U2 - 10.1039/d1tb00568e

DO - 10.1039/d1tb00568e

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AN - SCOPUS:85108677261

SN - 2050-7518

VL - 9

SP - 4857

EP - 4862

JO - Journal of Materials Chemistry B

JF - Journal of Materials Chemistry B

IS - 24

ER -

Novel quinoline-based fluorescent bioimaging probe, KSNP117, for sentinel lymph node mapping

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