Nuclear microenvironments support physiological control of gene expression

Gary S. Stein; Jane B. Lian; Martin Montecino; Janet L. Stein; André J. Van Wijnen; Amjad Javed; Jitesh Pratap; Je Choi; S. Kaleem Zaidi; Soraya Gutierrez; Kimberly Harrington; Jiali Shen; Daniel Young; Shirwin Pockwinse

doi:10.1023/A:1024943214431

Nuclear microenvironments support physiological control of gene expression

Gary S. Stein, Jane B. Lian, Martin Montecino, Janet L. Stein, André J. Van Wijnen, Amjad Javed, Jitesh Pratap, Je Choi, S. Kaleem Zaidi, Soraya Gutierrez, Kimberly Harrington, Jiali Shen, Daniel Young, Shirwin Pockwinse

Department of Medicine

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

There is growing recognition that the organization of nucleic acids and regulatory proteins is functionally linked to the assembly, localization and activity of gene regulatory machinery. Cellular, molecular, biochemical and in-vivo genetic evidence support an obligatory relationship between nuclear microenvironments where regulatory complexes reside and fidelity of transcriptional control. Perturbations in mechanisms governing the intranuclear trafficking of transcription factors and the temporal/spatial organization of regulatory proteins within the nucleus occur with compromised gene expression that abrogates skeletal development and mediates leukemogenesis.

Original language	English
Pages (from-to)	527-536
Number of pages	10
Journal	Chromosome Research
Volume	11
Issue number	5
DOIs	https://doi.org/10.1023/A:1024943214431
State	Published - 2003

Keywords

Cell nucleus
Chromatin
Gene expression
Nucleosome
Osteocalcin
RUNX proteins

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title = "Nuclear microenvironments support physiological control of gene expression",

abstract = "There is growing recognition that the organization of nucleic acids and regulatory proteins is functionally linked to the assembly, localization and activity of gene regulatory machinery. Cellular, molecular, biochemical and in-vivo genetic evidence support an obligatory relationship between nuclear microenvironments where regulatory complexes reside and fidelity of transcriptional control. Perturbations in mechanisms governing the intranuclear trafficking of transcription factors and the temporal/spatial organization of regulatory proteins within the nucleus occur with compromised gene expression that abrogates skeletal development and mediates leukemogenesis.",

keywords = "Cell nucleus, Chromatin, Gene expression, Nucleosome, Osteocalcin, RUNX proteins",

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language = "English",

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pages = "527--536",

journal = "Chromosome Research",

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T1 - Nuclear microenvironments support physiological control of gene expression

AU - Stein, Gary S.

AU - Lian, Jane B.

AU - Montecino, Martin

AU - Stein, Janet L.

AU - Van Wijnen, André J.

AU - Javed, Amjad

AU - Pratap, Jitesh

AU - Choi, Je

AU - Zaidi, S. Kaleem

AU - Gutierrez, Soraya

AU - Harrington, Kimberly

AU - Shen, Jiali

AU - Young, Daniel

AU - Pockwinse, Shirwin

PY - 2003

Y1 - 2003

N2 - There is growing recognition that the organization of nucleic acids and regulatory proteins is functionally linked to the assembly, localization and activity of gene regulatory machinery. Cellular, molecular, biochemical and in-vivo genetic evidence support an obligatory relationship between nuclear microenvironments where regulatory complexes reside and fidelity of transcriptional control. Perturbations in mechanisms governing the intranuclear trafficking of transcription factors and the temporal/spatial organization of regulatory proteins within the nucleus occur with compromised gene expression that abrogates skeletal development and mediates leukemogenesis.

AB - There is growing recognition that the organization of nucleic acids and regulatory proteins is functionally linked to the assembly, localization and activity of gene regulatory machinery. Cellular, molecular, biochemical and in-vivo genetic evidence support an obligatory relationship between nuclear microenvironments where regulatory complexes reside and fidelity of transcriptional control. Perturbations in mechanisms governing the intranuclear trafficking of transcription factors and the temporal/spatial organization of regulatory proteins within the nucleus occur with compromised gene expression that abrogates skeletal development and mediates leukemogenesis.

KW - Cell nucleus

KW - Chromatin

KW - Gene expression

KW - Nucleosome

KW - Osteocalcin

KW - RUNX proteins

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DO - 10.1023/A:1024943214431

M3 - Article

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AN - SCOPUS:10744232700

SN - 0967-3849

VL - 11

SP - 527

EP - 536

JO - Chromosome Research

JF - Chromosome Research

IS - 5

ER -

Nuclear microenvironments support physiological control of gene expression

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Keywords

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