Numerical study on the complete blood cell sorting using particle tracing and dielectrophoresis in a microfluidic device

Haider Ali, Cheol Woo Park

Research output: Contribution to journalArticlepeer-review

21 Scopus citations

Abstract

In this study, a numerical model of a microfluidic device with particle tracing and dielectrophoresis fieldflow fractionation was employed to perform a complete and continuous blood cell sorting. A low voltage was applied to electrodes to separate the red blood cells, white blood cells, and platelets based on their cell size. Blood cell sorting and counting were performed by evaluating the cell trajectories, displacements, residence times, and recovery rates in the device. A novel numerical technique was used to count the number of separated blood cells by estimating the displacement and residence time of the cells in a microfluidic device. For successful blood cell sorting, the value of cells displacement must be approximately equal to or higher than the corresponding maximum streamwise distance. The study also proposed different outlet designs to improve blood cell separation. The basic outlet design resulted in a higher cells recovery rate than the other outlets design. The recovery rate decreased as the number of inlet cells and flow rates increased because of the high particle-particle interactions and collisions with walls. The particle-particle interactions significantly affect blood cell sorting and must therefore be considered in future work.

Original languageEnglish
Pages (from-to)327-339
Number of pages13
JournalKorea Australia Rheology Journal
Volume28
Issue number4
DOIs
StatePublished - Nov 2016

Keywords

  • Blood transfusion
  • Cell sorting
  • Dielectrophoresis
  • Particle tracing
  • Recovery rate

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