Odorless isocyanide chemistry: An integrated microfluidic system for a multistep reaction sequence

Siddharth Sharma; Ram Awatar Maurya; Kyoung Ik Min; Guan Young Jeong; Dong Pyo Kim

doi:10.1002/anie.201303213

Odorless isocyanide chemistry: An integrated microfluidic system for a multistep reaction sequence

Siddharth Sharma, Ram Awatar Maurya, Kyoung Ik Min, Guan Young Jeong, Dong Pyo Kim

Major in Biomedical Convergence Science & Technology

Research output: Contribution to journal › Article › peer-review

101 Scopus citations

Abstract

Can't smell this: An integrated continuous-flow microfluidic setup enables in situ generation, extraction, separation, and reaction of foul-smelling isocyanides with little exposure to the surroundings. Isocyanides were generated by dehydration of the corresponding N-substituted formamides, and several representative isocyanide-based organic reactions were successfully performed. DIPEA=N,N-diisopropylethylamine.

Original language	English
Pages (from-to)	7564-7568
Number of pages	5
Journal	Angewandte Chemie - International Edition
Volume	52
Issue number	29
DOIs	https://doi.org/10.1002/anie.201303213
State	Published - 15 Jul 2013

Keywords

continuous flow
isocyanides
microreactors
multi-component reactions
organometallics

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10.1002/anie.201303213

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abstract = "Can't smell this: An integrated continuous-flow microfluidic setup enables in situ generation, extraction, separation, and reaction of foul-smelling isocyanides with little exposure to the surroundings. Isocyanides were generated by dehydration of the corresponding N-substituted formamides, and several representative isocyanide-based organic reactions were successfully performed. DIPEA=N,N-diisopropylethylamine.",

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AU - Jeong, Guan Young

AU - Kim, Dong Pyo

PY - 2013/7/15

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AB - Can't smell this: An integrated continuous-flow microfluidic setup enables in situ generation, extraction, separation, and reaction of foul-smelling isocyanides with little exposure to the surroundings. Isocyanides were generated by dehydration of the corresponding N-substituted formamides, and several representative isocyanide-based organic reactions were successfully performed. DIPEA=N,N-diisopropylethylamine.

KW - continuous flow

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KW - microreactors

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KW - organometallics

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Odorless isocyanide chemistry: An integrated microfluidic system for a multistep reaction sequence

Abstract

Keywords

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