Oestradiol-17β is a local factor inducing the early stage of spermatogenesis in mouse testes

K. G. Kim; Y. S. Park

doi:10.1111/and.12905

Oestradiol-17β is a local factor inducing the early stage of spermatogenesis in mouse testes

K. G. Kim, Y. S. Park

Department of Animal Biotechnology

Yanbian University

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

This study was undertaken to elucidate the effect of testicular oestradiol-17β (E₂) on spermatogenesis. Spermatogonial development and spermatogenic gene expression in testicular germ cells were investigated using an in vitro culture system supplemented with E₂. E₂ stimulated spermatocytogenic development of cultured testicular germ cells regardless of the addition of follicle-stimulating hormone and testosterone to the culture medium. E₂ also induced the expression of genes encoding synaptonemal complex protein 1 and protamine 1, proteins required for spermatogenesis. In conclusion, the results of this study suggest that E₂ is a spermatocytogenic factor that acts via the stimulation of spermatogenic gene expression.

Original language	English
Article number	e12905
Journal	Andrologia
Volume	50
Issue number	3
DOIs	https://doi.org/10.1111/and.12905
State	Published - Apr 2018

Keywords

follicle-stimulating hormone
oestradiol-17β
spermatocytogenesis
testicular germ cells
testosterone

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10.1111/and.12905

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title = "Oestradiol-17β is a local factor inducing the early stage of spermatogenesis in mouse testes",

abstract = "This study was undertaken to elucidate the effect of testicular oestradiol-17β (E2) on spermatogenesis. Spermatogonial development and spermatogenic gene expression in testicular germ cells were investigated using an in vitro culture system supplemented with E2. E2 stimulated spermatocytogenic development of cultured testicular germ cells regardless of the addition of follicle-stimulating hormone and testosterone to the culture medium. E2 also induced the expression of genes encoding synaptonemal complex protein 1 and protamine 1, proteins required for spermatogenesis. In conclusion, the results of this study suggest that E2 is a spermatocytogenic factor that acts via the stimulation of spermatogenic gene expression.",

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author = "Kim, {K. G.} and Park, {Y. S.}",

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AU - Kim, K. G.

AU - Park, Y. S.

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N2 - This study was undertaken to elucidate the effect of testicular oestradiol-17β (E2) on spermatogenesis. Spermatogonial development and spermatogenic gene expression in testicular germ cells were investigated using an in vitro culture system supplemented with E2. E2 stimulated spermatocytogenic development of cultured testicular germ cells regardless of the addition of follicle-stimulating hormone and testosterone to the culture medium. E2 also induced the expression of genes encoding synaptonemal complex protein 1 and protamine 1, proteins required for spermatogenesis. In conclusion, the results of this study suggest that E2 is a spermatocytogenic factor that acts via the stimulation of spermatogenic gene expression.

AB - This study was undertaken to elucidate the effect of testicular oestradiol-17β (E2) on spermatogenesis. Spermatogonial development and spermatogenic gene expression in testicular germ cells were investigated using an in vitro culture system supplemented with E2. E2 stimulated spermatocytogenic development of cultured testicular germ cells regardless of the addition of follicle-stimulating hormone and testosterone to the culture medium. E2 also induced the expression of genes encoding synaptonemal complex protein 1 and protamine 1, proteins required for spermatogenesis. In conclusion, the results of this study suggest that E2 is a spermatocytogenic factor that acts via the stimulation of spermatogenic gene expression.

KW - follicle-stimulating hormone

KW - oestradiol-17β

KW - spermatocytogenesis

KW - testicular germ cells

KW - testosterone

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JO - Andrologia

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ER -

Oestradiol-17β is a local factor inducing the early stage of spermatogenesis in mouse testes

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