On-DNA Mannich Reaction for DNA-Encoded Library Synthesis

Danila Ryzhikh; Hyewon Seo; Jihoon Lee; Jieon Lee; Myung Hee Nam; Minsoo Song; Gil Tae Hwang

doi:10.1021/acs.joc.4c02098

On-DNA Mannich Reaction for DNA-Encoded Library Synthesis

Danila Ryzhikh, Hyewon Seo, Jihoon Lee, Jieon Lee, Myung Hee Nam, Minsoo Song, Gil Tae Hwang

Research output: Contribution to journal › Article › peer-review

Abstract

The β-amino ketones produced through the Mannich reaction hold significant potential as candidates for various drugs. In this study, we optimized on-DNA Mannich reaction conditions and applied them to investigate the reactions of DNA-conjugated aldehydes with various amine and ketone building blocks. The developed on-DNA Mannich reaction preserved the DNA integrity and established viable routes for library production. These results underscore the potential of the Mannich reaction in DNA-encoded library (DEL) synthesis.

Original language	English
Pages (from-to)	16957-16963
Number of pages	7
Journal	Journal of Organic Chemistry
Volume	89
Issue number	22
DOIs	https://doi.org/10.1021/acs.joc.4c02098
State	Published - 15 Nov 2024

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10.1021/acs.joc.4c02098

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title = "On-DNA Mannich Reaction for DNA-Encoded Library Synthesis",

abstract = "The β-amino ketones produced through the Mannich reaction hold significant potential as candidates for various drugs. In this study, we optimized on-DNA Mannich reaction conditions and applied them to investigate the reactions of DNA-conjugated aldehydes with various amine and ketone building blocks. The developed on-DNA Mannich reaction preserved the DNA integrity and established viable routes for library production. These results underscore the potential of the Mannich reaction in DNA-encoded library (DEL) synthesis.",

author = "Danila Ryzhikh and Hyewon Seo and Jihoon Lee and Jieon Lee and Nam, {Myung Hee} and Minsoo Song and Hwang, {Gil Tae}",

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AU - Ryzhikh, Danila

AU - Seo, Hyewon

AU - Lee, Jihoon

AU - Lee, Jieon

AU - Nam, Myung Hee

AU - Song, Minsoo

AU - Hwang, Gil Tae

PY - 2024/11/15

Y1 - 2024/11/15

N2 - The β-amino ketones produced through the Mannich reaction hold significant potential as candidates for various drugs. In this study, we optimized on-DNA Mannich reaction conditions and applied them to investigate the reactions of DNA-conjugated aldehydes with various amine and ketone building blocks. The developed on-DNA Mannich reaction preserved the DNA integrity and established viable routes for library production. These results underscore the potential of the Mannich reaction in DNA-encoded library (DEL) synthesis.

AB - The β-amino ketones produced through the Mannich reaction hold significant potential as candidates for various drugs. In this study, we optimized on-DNA Mannich reaction conditions and applied them to investigate the reactions of DNA-conjugated aldehydes with various amine and ketone building blocks. The developed on-DNA Mannich reaction preserved the DNA integrity and established viable routes for library production. These results underscore the potential of the Mannich reaction in DNA-encoded library (DEL) synthesis.

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U2 - 10.1021/acs.joc.4c02098

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M3 - Article

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JO - Journal of Organic Chemistry

JF - Journal of Organic Chemistry

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ER -

On-DNA Mannich Reaction for DNA-Encoded Library Synthesis

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