Optical detection of deoxyribonucleic acid hybridization using an anchoring transition of liquid crystal alignment

Hak Rin Kim; Jae Hoon Kim; Tae Sun Kim; Sang Wook Oh; Eui Yul Choi

doi:10.1063/1.2077859

Optical detection of deoxyribonucleic acid hybridization using an anchoring transition of liquid crystal alignment

Hak Rin Kim, Jae Hoon Kim, Tae Sun Kim, Sang Wook Oh, Eui Yul Choi

School of Electronics Engineering

Research output: Contribution to journal › Article › peer-review

31 Scopus citations

Abstract

We demonstrate an optical method for detecting specific binding events in an oligo deoxyribonucleic acid (DNA) chip using an anchoring transition of a nematic liquid crystal (NLC) as a result of DNA hybridization. A homeotropic orientation of the NLC supported by oligoDNA changes to a random planar orientation after hybridization. Such DNA hybridization and subsequent NLC reorientation are easily observable with a simple detection system via long-range orientational order and large optical anisotropy of the NLC.

Original language	English
Article number	143901
Pages (from-to)	1-3
Number of pages	3
Journal	Applied Physics Letters
Volume	87
Issue number	14
DOIs	https://doi.org/10.1063/1.2077859
State	Published - 3 Oct 2005

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10.1063/1.2077859

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abstract = "We demonstrate an optical method for detecting specific binding events in an oligo deoxyribonucleic acid (DNA) chip using an anchoring transition of a nematic liquid crystal (NLC) as a result of DNA hybridization. A homeotropic orientation of the NLC supported by oligoDNA changes to a random planar orientation after hybridization. Such DNA hybridization and subsequent NLC reorientation are easily observable with a simple detection system via long-range orientational order and large optical anisotropy of the NLC.",

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AU - Choi, Eui Yul

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AB - We demonstrate an optical method for detecting specific binding events in an oligo deoxyribonucleic acid (DNA) chip using an anchoring transition of a nematic liquid crystal (NLC) as a result of DNA hybridization. A homeotropic orientation of the NLC supported by oligoDNA changes to a random planar orientation after hybridization. Such DNA hybridization and subsequent NLC reorientation are easily observable with a simple detection system via long-range orientational order and large optical anisotropy of the NLC.

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Optical detection of deoxyribonucleic acid hybridization using an anchoring transition of liquid crystal alignment

Abstract

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