Optical detection of deoxyribonucleic acid hybridization using an anchoring transition of liquid crystal alignment

Hak Rin Kim; Jae Hoon Kim; Tae Sun Kim; Sang Wook Oh; Eui Yul Choi

doi:10.1063/1.2077859

Optical detection of deoxyribonucleic acid hybridization using an anchoring transition of liquid crystal alignment

Hak Rin Kim
, Jae Hoon Kim
, Tae Sun Kim
, Sang Wook Oh
, Eui Yul Choi

School of Electronics Engineering

Research output: Contribution to journal › Article › peer-review

35 Scopus citations

Abstract

We demonstrate an optical method for detecting specific binding events in an oligo deoxyribonucleic acid (DNA) chip using an anchoring transition of a nematic liquid crystal (NLC) as a result of DNA hybridization. A homeotropic orientation of the NLC supported by oligoDNA changes to a random planar orientation after hybridization. Such DNA hybridization and subsequent NLC reorientation are easily observable with a simple detection system via long-range orientational order and large optical anisotropy of the NLC.

Original language	English
Article number	143901
Pages (from-to)	1-3
Number of pages	3
Journal	Applied Physics Letters
Volume	87
Issue number	14
DOIs	https://doi.org/10.1063/1.2077859
State	Published - 3 Oct 2005

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abstract = "We demonstrate an optical method for detecting specific binding events in an oligo deoxyribonucleic acid (DNA) chip using an anchoring transition of a nematic liquid crystal (NLC) as a result of DNA hybridization. A homeotropic orientation of the NLC supported by oligoDNA changes to a random planar orientation after hybridization. Such DNA hybridization and subsequent NLC reorientation are easily observable with a simple detection system via long-range orientational order and large optical anisotropy of the NLC.",

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AU - Kim, Hak Rin

AU - Kim, Jae Hoon

AU - Kim, Tae Sun

AU - Oh, Sang Wook

AU - Choi, Eui Yul

PY - 2005/10/3

Y1 - 2005/10/3

N2 - We demonstrate an optical method for detecting specific binding events in an oligo deoxyribonucleic acid (DNA) chip using an anchoring transition of a nematic liquid crystal (NLC) as a result of DNA hybridization. A homeotropic orientation of the NLC supported by oligoDNA changes to a random planar orientation after hybridization. Such DNA hybridization and subsequent NLC reorientation are easily observable with a simple detection system via long-range orientational order and large optical anisotropy of the NLC.

AB - We demonstrate an optical method for detecting specific binding events in an oligo deoxyribonucleic acid (DNA) chip using an anchoring transition of a nematic liquid crystal (NLC) as a result of DNA hybridization. A homeotropic orientation of the NLC supported by oligoDNA changes to a random planar orientation after hybridization. Such DNA hybridization and subsequent NLC reorientation are easily observable with a simple detection system via long-range orientational order and large optical anisotropy of the NLC.

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U2 - 10.1063/1.2077859

DO - 10.1063/1.2077859

M3 - Article

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Optical detection of deoxyribonucleic acid hybridization using an anchoring transition of liquid crystal alignment

Abstract

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