TY - JOUR
T1 - Optimization of in vivo X-ray fluorescence analysis methods for bone lead by simulation with the Monte Carlo code CEARXRF
AU - Ao, Q.
AU - Lee, S. H.
AU - Gardner, R. P.
PY - 1997/10
Y1 - 1997/10
N2 - In the design of X-ray fluorescence (XRF) systems for in vivo measurements of lead in human bone, the most important considerations are the minimum detectable concentration (MDC), and accuracy and precision. Possible design optimizations can be investigated much more easily and economically by Monte Carlo simulation than by experiment. The specific purpose Monte Carlo code CEARXRF has been used in the present study for: (1) improving the MDC of a hypothesized in vivo 109Cd source-based KXRF system and a 109Cd source or X-ray tube source-based LXRF system by investigating the effects of source polarization and source-bone-detector geometry modification on reducing the scattering background, and (2) investigating the effects of sample variables, such as overlying skin thickness on the MDC and the lead XRF intensity precision. In addition, the feasibility of the Monte Carlo- Library Least-Squares (MCLLS) approach has been investigated in a preliminary fashion for 109Cd-based KXRF spectroscopy analysis.
AB - In the design of X-ray fluorescence (XRF) systems for in vivo measurements of lead in human bone, the most important considerations are the minimum detectable concentration (MDC), and accuracy and precision. Possible design optimizations can be investigated much more easily and economically by Monte Carlo simulation than by experiment. The specific purpose Monte Carlo code CEARXRF has been used in the present study for: (1) improving the MDC of a hypothesized in vivo 109Cd source-based KXRF system and a 109Cd source or X-ray tube source-based LXRF system by investigating the effects of source polarization and source-bone-detector geometry modification on reducing the scattering background, and (2) investigating the effects of sample variables, such as overlying skin thickness on the MDC and the lead XRF intensity precision. In addition, the feasibility of the Monte Carlo- Library Least-Squares (MCLLS) approach has been investigated in a preliminary fashion for 109Cd-based KXRF spectroscopy analysis.
UR - http://www.scopus.com/inward/record.url?scp=0031251909&partnerID=8YFLogxK
U2 - 10.1016/S0969-8043(97)00137-1
DO - 10.1016/S0969-8043(97)00137-1
M3 - Article
C2 - 9463867
AN - SCOPUS:0031251909
SN - 0969-8043
VL - 48
SP - 1413
EP - 1423
JO - Applied Radiation and Isotopes
JF - Applied Radiation and Isotopes
IS - 10-12
ER -