Osteogenetic effects of calcium sulfate, demineralized bone matrix, and calcium metaphosphate in a canine femur with unicortical defects

Jang Yoon Choi, Se Il Park, Young Sam Kwon, Kwang Ho Jang

Research output: Contribution to journalArticlepeer-review

Abstract

The purpose of this experiment was to study the effects of demineralized bone matrix (DBM), calcium sulfate (CS), and calcium metaphosphate (CMP) on osteogenesis of unicortical 5-mm-diameter defects in canine femurs. Seventy-two femoral unicortical defects of nine adult beagles (eighteen femurs, four unicortical femoral defects were made in each femur) were made. Three bone graft substitutive materials such as CS, DBM, and CMP and the empty controls were compared each other. The postimplanted specimens were harvested at week 4, 8, and 24 for radiographic, biochemical and histomorphologic evaluation. In radiograph, CS group appeared to be absorbed rapidly and made new cortical bone. Defects of cortical bone was gradually filled with new bone around bone graft materials in DBM group. Bone graft substitutes weren't absorbed rapidly but, remained performing structural roles in cortical bone after 24 weeks in CMP group. Radiographic intensity of control group showed significantly (p < 0.05) lower compared to that of experimental group. Defects treated with either CS, DBM or CMP had more bone formation than the untreated defects (p < 0.05). The results of analysis in the cortical bone region were deduced the conclusions as follows. Three bone graft materials seemed to accelerate the formation of new bone compared with controls for 24 weeks. CMP group having more or less large particle space was more adequate than DBM group, as well as more compact CS group was more pertinent than CMP group as the glues for bones.

Original languageEnglish
Pages (from-to)652-662
Number of pages11
JournalJournal of Veterinary Clinics
Volume27
Issue number6
StatePublished - 2010

Keywords

  • Calcium metaphosphate
  • Calcium sulfate
  • Demineralized bone matrix
  • Osteogenesis

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