p-Terphenyls from the fruiting bodies of Paxillus curtisii and their antioxidant properties

In Kyoung Lee, Jin Young Jung, Young Sook Kim, Man Hee Rhee, Bong Sik Yun

Research output: Contribution to journalArticlepeer-review

38 Scopus citations

Abstract

New p-terphenyls, curtisians R (1)-V (5), have been isolated together with known compounds, curtisians E, I-P, and kynapcin-12, from the methanolic extract of the fruiting bodies of Paxillus curtisii (Paxillaceace). Their structures were established by various spectroscopic analyses including 1D- and 2D-NMR experiments, as well as high-resolution FAB-mass analysis. They exhibited significant protective effects against oxidative damage of supercoiled DNA and 2-deoxyribose by hydroxyl radicals generated from the Fenton reaction.

Original languageEnglish
Pages (from-to)4674-4680
Number of pages7
JournalBioorganic and Medicinal Chemistry
Volume17
Issue number13
DOIs
StatePublished - 1 Jul 2009

Keywords

  • Curtisians
  • Fenton reaction
  • Free radical scavengers
  • p-Terphenyls
  • Paxillus curtisii

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