Abstract
New p-terphenyls, curtisians R (1)-V (5), have been isolated together with known compounds, curtisians E, I-P, and kynapcin-12, from the methanolic extract of the fruiting bodies of Paxillus curtisii (Paxillaceace). Their structures were established by various spectroscopic analyses including 1D- and 2D-NMR experiments, as well as high-resolution FAB-mass analysis. They exhibited significant protective effects against oxidative damage of supercoiled DNA and 2-deoxyribose by hydroxyl radicals generated from the Fenton reaction.
Original language | English |
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Pages (from-to) | 4674-4680 |
Number of pages | 7 |
Journal | Bioorganic and Medicinal Chemistry |
Volume | 17 |
Issue number | 13 |
DOIs | |
State | Published - 1 Jul 2009 |
Keywords
- Curtisians
- Fenton reaction
- Free radical scavengers
- p-Terphenyls
- Paxillus curtisii