Palladium-catalysed convenient synthesis of 3-methyleneisoindolin-1-ones

Chan Sik Cho, Hyung Sup Shim, Heung Jin Choi, Tae Jeong Kim, Sang Chul Shim

Research output: Contribution to journalArticlepeer-review

24 Scopus citations

Abstract

2′-Bromoacetophenone reacts with an array of aliphatic primary amines under carbon monoxide pressure in the presence of a catalytic amount of a palladium catalyst to afford 3-methyleneisoindolin-1-ones in moderate yields.

Original languageEnglish
Pages (from-to)1821-1827
Number of pages7
JournalSynthetic Communications
Volume32
Issue number12
DOIs
StatePublished - 2002

Keywords

  • Carbon monoxide
  • Cyclisation
  • Isoindolinone
  • Palladium
  • Primary amine

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