Palladium-catalyzed C-N bond formation: synthesis of 1-aryl-1H-pyrazoles from β-bromovinyl aldehydes and arylhydrazines

Chan Sik Cho; Daksha B. Patel

doi:10.1016/j.tet.2006.04.031

Palladium-catalyzed C-N bond formation: synthesis of 1-aryl-1H-pyrazoles from β-bromovinyl aldehydes and arylhydrazines

Chan Sik Cho, Daksha B. Patel

Department of Applied Chemistry

Kyungpook National University

Research output: Contribution to journal › Article › peer-review

49 Scopus citations

Abstract

Cyclic and acyclic β-bromovinyl aldehydes are cyclized with an array of arylhydrazines in toluene at 125 °C in the presence of a palladium catalyst and a phosphorus chelating ligand together with NaO^tBu to give 1-aryl-1H-pyrazoles in moderate to good yields.

Original language	English
Pages (from-to)	6388-6391
Number of pages	4
Journal	Tetrahedron
Volume	62
Issue number	26
DOIs	https://doi.org/10.1016/j.tet.2006.04.031
State	Published - 26 Jun 2006

Keywords

β-Bromovinyl aldehydes
Arylhydrazines
C-N bond formation
Palladium catalyst
Pyrazoles

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10.1016/j.tet.2006.04.031

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title = "Palladium-catalyzed C-N bond formation: synthesis of 1-aryl-1H-pyrazoles from β-bromovinyl aldehydes and arylhydrazines",

abstract = "Cyclic and acyclic β-bromovinyl aldehydes are cyclized with an array of arylhydrazines in toluene at 125 °C in the presence of a palladium catalyst and a phosphorus chelating ligand together with NaOtBu to give 1-aryl-1H-pyrazoles in moderate to good yields.",

keywords = "β-Bromovinyl aldehydes, Arylhydrazines, C-N bond formation, Palladium catalyst, Pyrazoles",

author = "Cho, {Chan Sik} and Patel, {Daksha B.}",

year = "2006",

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language = "English",

volume = "62",

pages = "6388--6391",

journal = "Tetrahedron",

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T1 - Palladium-catalyzed C-N bond formation

T2 - synthesis of 1-aryl-1H-pyrazoles from β-bromovinyl aldehydes and arylhydrazines

AU - Cho, Chan Sik

AU - Patel, Daksha B.

PY - 2006/6/26

Y1 - 2006/6/26

N2 - Cyclic and acyclic β-bromovinyl aldehydes are cyclized with an array of arylhydrazines in toluene at 125 °C in the presence of a palladium catalyst and a phosphorus chelating ligand together with NaOtBu to give 1-aryl-1H-pyrazoles in moderate to good yields.

AB - Cyclic and acyclic β-bromovinyl aldehydes are cyclized with an array of arylhydrazines in toluene at 125 °C in the presence of a palladium catalyst and a phosphorus chelating ligand together with NaOtBu to give 1-aryl-1H-pyrazoles in moderate to good yields.

KW - β-Bromovinyl aldehydes

KW - Arylhydrazines

KW - C-N bond formation

KW - Palladium catalyst

KW - Pyrazoles

UR - http://www.scopus.com/inward/record.url?scp=33646797446&partnerID=8YFLogxK

U2 - 10.1016/j.tet.2006.04.031

DO - 10.1016/j.tet.2006.04.031

M3 - Article

AN - SCOPUS:33646797446

SN - 0040-4020

VL - 62

SP - 6388

EP - 6391

JO - Tetrahedron

JF - Tetrahedron

IS - 26

ER -

Palladium-catalyzed C-N bond formation: synthesis of 1-aryl-1H-pyrazoles from β-bromovinyl aldehydes and arylhydrazines

Abstract

Keywords

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