Palladium-catalyzed carbonylative cyclization of 2-bromobenzaldehyde with primary amines leading to isoindolin-1-ones

Chan Sik Cho, Wen Xiu Ren

Research output: Contribution to journalArticlepeer-review

44 Scopus citations

Abstract

2-Bromobenzaldehyde is carbonylatively cyclized with primary amines under carbon monoxide pressure in DMF at 100 °C in the presence of a catalytic amount of a palladium catalyst to give the corresponding isoindolin-1-ones in moderate to high yields.

Original languageEnglish
Pages (from-to)2097-2099
Number of pages3
JournalTetrahedron Letters
Volume50
Issue number18
DOIs
StatePublished - 6 May 2009

Keywords

  • 2-Bromobenzaldehyde
  • Carbonylative cyclization
  • Isoindolin-1-ones
  • Palladium catalyst
  • Primary amines

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