Palladium-catalyzed cyclization of β-bromo-α,β-unsaturated ketones with arylhydrazines leading to 3-substituted 1-aryl-1 H-pyrazoles

Hye Kyung Lee; Chan Sik Cho

doi:10.1002/aoc.2900

Palladium-catalyzed cyclization of β-bromo-α,β-unsaturated ketones with arylhydrazines leading to 3-substituted 1-aryl-1 H-pyrazoles

Hye Kyung Lee, Chan Sik Cho

Department of Applied Chemistry

Kyungpook National University

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

β-Bromo-α,β-unsaturated ketones are condensed with arylhydrazines to form hydrazones, which are in situ intramolecularly cyclized into 3-substituted 1-aryl-1 H-pyrazoles under a catalytic system of Pd(OAc) ₂/1,3-bis(diphenylhosphino)propane (dppp)/NaO ^tBu.

Original language	English
Pages (from-to)	570-575
Number of pages	6
Journal	Applied Organometallic Chemistry
Volume	26
Issue number	11
DOIs	https://doi.org/10.1002/aoc.2900
State	Published - Nov 2012

Keywords

β-bromo-α,β-unsaturated ketones
1-aryl-1 H-pyrazoles
arylhydrazines
C-N bond formation
palladium catalyst

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10.1002/aoc.2900

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title = "Palladium-catalyzed cyclization of β-bromo-α,β-unsaturated ketones with arylhydrazines leading to 3-substituted 1-aryl-1 H-pyrazoles",

abstract = "β-Bromo-α,β-unsaturated ketones are condensed with arylhydrazines to form hydrazones, which are in situ intramolecularly cyclized into 3-substituted 1-aryl-1 H-pyrazoles under a catalytic system of Pd(OAc) 2/1,3-bis(diphenylhosphino)propane (dppp)/NaO tBu.",

keywords = "β-bromo-α,β-unsaturated ketones, 1-aryl-1 H-pyrazoles, arylhydrazines, C-N bond formation, palladium catalyst",

author = "Lee, {Hye Kyung} and Cho, {Chan Sik}",

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AU - Cho, Chan Sik

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N2 - β-Bromo-α,β-unsaturated ketones are condensed with arylhydrazines to form hydrazones, which are in situ intramolecularly cyclized into 3-substituted 1-aryl-1 H-pyrazoles under a catalytic system of Pd(OAc) 2/1,3-bis(diphenylhosphino)propane (dppp)/NaO tBu.

AB - β-Bromo-α,β-unsaturated ketones are condensed with arylhydrazines to form hydrazones, which are in situ intramolecularly cyclized into 3-substituted 1-aryl-1 H-pyrazoles under a catalytic system of Pd(OAc) 2/1,3-bis(diphenylhosphino)propane (dppp)/NaO tBu.

KW - β-bromo-α,β-unsaturated ketones

KW - 1-aryl-1 H-pyrazoles

KW - arylhydrazines

KW - C-N bond formation

KW - palladium catalyst

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DO - 10.1002/aoc.2900

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SP - 570

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JO - Applied Organometallic Chemistry

JF - Applied Organometallic Chemistry

IS - 11

ER -

Palladium-catalyzed cyclization of β-bromo-α,β-unsaturated ketones with arylhydrazines leading to 3-substituted 1-aryl-1 H-pyrazoles

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Keywords

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