TY - JOUR
T1 - Paper Spray Chemical Ionization
T2 - Highly Sensitive Ambient Ionization Method for Low- and Nonpolar Aromatic Compounds
AU - Kim, Donghwi
AU - Yim, Un Hyuk
AU - Kim, Byungjoo
AU - Cha, Sangwon
AU - Kim, Sunghwan
N1 - Publisher Copyright:
© 2017 American Chemical Society.
PY - 2017/9/5
Y1 - 2017/9/5
N2 - Sensitivity is an important factor determining successful mass spectrometry (MS) analysis of metabolome, protein, drugs, and environmental samples. Currently, nanoelectrospray ionization (ESI) is widely used as a sensitive ionization method. However, application of nano-ESI is limited to polar molecules and there is no atmospheric pressure ionization technique developed that can be used for MS analysis of low- and nonpolar compounds with sensitivity that can match with nano-ESI. Herein, we propose paper spray chemical ionization (PSCI) as an ionization technique that can be used to analyze low- and nonpolar aromatic compounds with high sensitivity. PSCI is based on paper spray ionization utilizing corona discharge phenomenon. PSCI can sensitively and quantitatively detect down to picogram (or femtomole) levels of low- and nonpolar aromatic compounds.
AB - Sensitivity is an important factor determining successful mass spectrometry (MS) analysis of metabolome, protein, drugs, and environmental samples. Currently, nanoelectrospray ionization (ESI) is widely used as a sensitive ionization method. However, application of nano-ESI is limited to polar molecules and there is no atmospheric pressure ionization technique developed that can be used for MS analysis of low- and nonpolar compounds with sensitivity that can match with nano-ESI. Herein, we propose paper spray chemical ionization (PSCI) as an ionization technique that can be used to analyze low- and nonpolar aromatic compounds with high sensitivity. PSCI is based on paper spray ionization utilizing corona discharge phenomenon. PSCI can sensitively and quantitatively detect down to picogram (or femtomole) levels of low- and nonpolar aromatic compounds.
UR - http://www.scopus.com/inward/record.url?scp=85028914944&partnerID=8YFLogxK
U2 - 10.1021/acs.analchem.7b01733
DO - 10.1021/acs.analchem.7b01733
M3 - Article
C2 - 28832128
AN - SCOPUS:85028914944
SN - 0003-2700
VL - 89
SP - 9056
EP - 9061
JO - Analytical Chemistry
JF - Analytical Chemistry
IS - 17
ER -