Paper Spray Chemical Ionization: Highly Sensitive Ambient Ionization Method for Low- and Nonpolar Aromatic Compounds

Donghwi Kim, Un Hyuk Yim, Byungjoo Kim, Sangwon Cha, Sunghwan Kim

Research output: Contribution to journalArticlepeer-review

32 Scopus citations

Abstract

Sensitivity is an important factor determining successful mass spectrometry (MS) analysis of metabolome, protein, drugs, and environmental samples. Currently, nanoelectrospray ionization (ESI) is widely used as a sensitive ionization method. However, application of nano-ESI is limited to polar molecules and there is no atmospheric pressure ionization technique developed that can be used for MS analysis of low- and nonpolar compounds with sensitivity that can match with nano-ESI. Herein, we propose paper spray chemical ionization (PSCI) as an ionization technique that can be used to analyze low- and nonpolar aromatic compounds with high sensitivity. PSCI is based on paper spray ionization utilizing corona discharge phenomenon. PSCI can sensitively and quantitatively detect down to picogram (or femtomole) levels of low- and nonpolar aromatic compounds.

Original languageEnglish
Pages (from-to)9056-9061
Number of pages6
JournalAnalytical Chemistry
Volume89
Issue number17
DOIs
StatePublished - 5 Sep 2017

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