Pathogenic genotype of major piroplasm surface protein associated with anemia in Theileria orientalis infection in cattle

Suhee Kim; Do Hyeon Yu; Jeong Byoung Chae; Kyoung Seong Choi; Hyeon Cheol Kim; Bae Keun Park; Joon Seok Chae; Jinho Park

doi:10.1186/s13028-017-0318-8

Pathogenic genotype of major piroplasm surface protein associated with anemia in Theileria orientalis infection in cattle

Suhee Kim, Do Hyeon Yu, Jeong Byoung Chae, Kyoung Seong Choi, Hyeon Cheol Kim, Bae Keun Park, Joon Seok Chae, Jinho Park

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

Serious disease outbreaks in cattle caused by Theileria orientalis have emerged in the Asia-Pacific region. Genetic variables of the major piroplasm surface protein (MPSP) expressed on the surface of the piroplasm inside T. orientalis-infected erythrocytes are considered to be associated with variation in the pathogenicity of T. orientalis. Our study describes the clinically relevant MPSP types associated with anemia in Theileria-infected cattle. These results revealed that MPSP expression plays an important role in hematological alterations in Theileria-infected cattle, and that MPSP type 1 is strongly associated with bovine anemia, which can be a potential target for the prevention of bovine theileriosis.

Original language	English
Article number	51
Journal	Acta Veterinaria Scandinavica
Volume	59
Issue number	1
DOIs	https://doi.org/10.1186/s13028-017-0318-8
State	Published - 27 Jul 2017

Keywords

Anemia
Major piroplasm surface protein
MPSP type 1
Theileria orientalis

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10.1186/s13028-017-0318-8

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title = "Pathogenic genotype of major piroplasm surface protein associated with anemia in Theileria orientalis infection in cattle",

abstract = "Serious disease outbreaks in cattle caused by Theileria orientalis have emerged in the Asia-Pacific region. Genetic variables of the major piroplasm surface protein (MPSP) expressed on the surface of the piroplasm inside T. orientalis-infected erythrocytes are considered to be associated with variation in the pathogenicity of T. orientalis. Our study describes the clinically relevant MPSP types associated with anemia in Theileria-infected cattle. These results revealed that MPSP expression plays an important role in hematological alterations in Theileria-infected cattle, and that MPSP type 1 is strongly associated with bovine anemia, which can be a potential target for the prevention of bovine theileriosis.",

keywords = "Anemia, Major piroplasm surface protein, MPSP type 1, Theileria orientalis",

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T1 - Pathogenic genotype of major piroplasm surface protein associated with anemia in Theileria orientalis infection in cattle

AU - Kim, Suhee

AU - Yu, Do Hyeon

AU - Chae, Jeong Byoung

AU - Choi, Kyoung Seong

AU - Kim, Hyeon Cheol

AU - Park, Bae Keun

AU - Chae, Joon Seok

AU - Park, Jinho

PY - 2017/7/27

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N2 - Serious disease outbreaks in cattle caused by Theileria orientalis have emerged in the Asia-Pacific region. Genetic variables of the major piroplasm surface protein (MPSP) expressed on the surface of the piroplasm inside T. orientalis-infected erythrocytes are considered to be associated with variation in the pathogenicity of T. orientalis. Our study describes the clinically relevant MPSP types associated with anemia in Theileria-infected cattle. These results revealed that MPSP expression plays an important role in hematological alterations in Theileria-infected cattle, and that MPSP type 1 is strongly associated with bovine anemia, which can be a potential target for the prevention of bovine theileriosis.

AB - Serious disease outbreaks in cattle caused by Theileria orientalis have emerged in the Asia-Pacific region. Genetic variables of the major piroplasm surface protein (MPSP) expressed on the surface of the piroplasm inside T. orientalis-infected erythrocytes are considered to be associated with variation in the pathogenicity of T. orientalis. Our study describes the clinically relevant MPSP types associated with anemia in Theileria-infected cattle. These results revealed that MPSP expression plays an important role in hematological alterations in Theileria-infected cattle, and that MPSP type 1 is strongly associated with bovine anemia, which can be a potential target for the prevention of bovine theileriosis.

KW - Anemia

KW - Major piroplasm surface protein

KW - MPSP type 1

KW - Theileria orientalis

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Pathogenic genotype of major piroplasm surface protein associated with anemia in Theileria orientalis infection in cattle

Abstract

Keywords

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