Pathogenic genotype of major piroplasm surface protein associated with anemia in Theileria orientalis infection in cattle

Suhee Kim; Do Hyeon Yu; Jeong Byoung Chae; Kyoung Seong Choi; Hyeon Cheol Kim; Bae Keun Park; Joon Seok Chae; Jinho Park

doi:10.1186/s13028-017-0318-8

Pathogenic genotype of major piroplasm surface protein associated with anemia in Theileria orientalis infection in cattle

Suhee Kim
, Do Hyeon Yu
, Jeong Byoung Chae
, Kyoung Seong Choi
, Hyeon Cheol Kim
, Bae Keun Park
, Joon Seok Chae
, Jinho Park

Rural Development Administration
Gyeongsang National University
Seoul National University
Kangwon National University
Chungnam National University
Jeonbuk National University

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

Serious disease outbreaks in cattle caused by Theileria orientalis have emerged in the Asia-Pacific region. Genetic variables of the major piroplasm surface protein (MPSP) expressed on the surface of the piroplasm inside T. orientalis-infected erythrocytes are considered to be associated with variation in the pathogenicity of T. orientalis. Our study describes the clinically relevant MPSP types associated with anemia in Theileria-infected cattle. These results revealed that MPSP expression plays an important role in hematological alterations in Theileria-infected cattle, and that MPSP type 1 is strongly associated with bovine anemia, which can be a potential target for the prevention of bovine theileriosis.

Original language	English
Article number	51
Journal	Acta Veterinaria Scandinavica
Volume	59
Issue number	1
DOIs	https://doi.org/10.1186/s13028-017-0318-8
State	Published - 27 Jul 2017

Keywords

Anemia
MPSP type 1
Major piroplasm surface protein
Theileria orientalis

Access to Document

10.1186/s13028-017-0318-8

Cite this

@article{329a7d12bc30414f8402e9a1e4257771,

title = "Pathogenic genotype of major piroplasm surface protein associated with anemia in Theileria orientalis infection in cattle",

abstract = "Serious disease outbreaks in cattle caused by Theileria orientalis have emerged in the Asia-Pacific region. Genetic variables of the major piroplasm surface protein (MPSP) expressed on the surface of the piroplasm inside T. orientalis-infected erythrocytes are considered to be associated with variation in the pathogenicity of T. orientalis. Our study describes the clinically relevant MPSP types associated with anemia in Theileria-infected cattle. These results revealed that MPSP expression plays an important role in hematological alterations in Theileria-infected cattle, and that MPSP type 1 is strongly associated with bovine anemia, which can be a potential target for the prevention of bovine theileriosis.",

keywords = "Anemia, MPSP type 1, Major piroplasm surface protein, Theileria orientalis",

author = "Suhee Kim and Yu, \{Do Hyeon\} and Chae, \{Jeong Byoung\} and Choi, \{Kyoung Seong\} and Kim, \{Hyeon Cheol\} and Park, \{Bae Keun\} and Chae, \{Joon Seok\} and Jinho Park",

note = "Publisher Copyright: {\textcopyright} 2017 The Author(s).",

year = "2017",

month = jul,

day = "27",

doi = "10.1186/s13028-017-0318-8",

language = "English",

volume = "59",

journal = "Acta Veterinaria Scandinavica",

issn = "0044-605X",

publisher = "BioMed Central Ltd.",

number = "1",

}

TY - JOUR

T1 - Pathogenic genotype of major piroplasm surface protein associated with anemia in Theileria orientalis infection in cattle

AU - Kim, Suhee

AU - Yu, Do Hyeon

AU - Chae, Jeong Byoung

AU - Choi, Kyoung Seong

AU - Kim, Hyeon Cheol

AU - Park, Bae Keun

AU - Chae, Joon Seok

AU - Park, Jinho

PY - 2017/7/27

Y1 - 2017/7/27

N2 - Serious disease outbreaks in cattle caused by Theileria orientalis have emerged in the Asia-Pacific region. Genetic variables of the major piroplasm surface protein (MPSP) expressed on the surface of the piroplasm inside T. orientalis-infected erythrocytes are considered to be associated with variation in the pathogenicity of T. orientalis. Our study describes the clinically relevant MPSP types associated with anemia in Theileria-infected cattle. These results revealed that MPSP expression plays an important role in hematological alterations in Theileria-infected cattle, and that MPSP type 1 is strongly associated with bovine anemia, which can be a potential target for the prevention of bovine theileriosis.

AB - Serious disease outbreaks in cattle caused by Theileria orientalis have emerged in the Asia-Pacific region. Genetic variables of the major piroplasm surface protein (MPSP) expressed on the surface of the piroplasm inside T. orientalis-infected erythrocytes are considered to be associated with variation in the pathogenicity of T. orientalis. Our study describes the clinically relevant MPSP types associated with anemia in Theileria-infected cattle. These results revealed that MPSP expression plays an important role in hematological alterations in Theileria-infected cattle, and that MPSP type 1 is strongly associated with bovine anemia, which can be a potential target for the prevention of bovine theileriosis.

KW - Anemia

KW - MPSP type 1

KW - Major piroplasm surface protein

KW - Theileria orientalis

UR - https://www.scopus.com/pages/publications/85026392000

U2 - 10.1186/s13028-017-0318-8

DO - 10.1186/s13028-017-0318-8

M3 - Article

C2 - 28750636

AN - SCOPUS:85026392000

SN - 0044-605X

VL - 59

JO - Acta Veterinaria Scandinavica

JF - Acta Veterinaria Scandinavica

IS - 1

M1 - 51

ER -

Pathogenic genotype of major piroplasm surface protein associated with anemia in Theileria orientalis infection in cattle

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this