Pattern of local recurrence after mastectomy and reconstruction in breast cancer patients: A systematic review

Ji Hyeon Joo, Yongkan Ki, Wontaek Kim, Jiho Nam, Donghyun Kim, Jongmoo Park, Hyun Yul Kim, Youn Joo Jung, Ki Seok Choo, Kyung Jin Nam, Su Bong Nam

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

Background: This study aimed to describe the locations of local recurrences based on the mastectomy and reconstruction type in breast cancer patients. Methods: In November 2020, a systematic literature review was performed through MEDLINE/PubMed and the Cochrane Centre Register of Controlled Trials. Publications that included skin-sparing or nipple-sparing mastectomy followed by breast reconstruction and described the location of local recurrences were analyzed. Exclusion criteria included salvage or prophylactic mastectomy, unclear distinction between local and regional recurrences, rare tumor types. Results: From 19 publications, 272 local recurrences lesions were reported in a total of 4,787 patients. After autologous reconstruction (n=2,465), local recurrences were located in the skin in 45 (1.8%) patients, in the chest wall in 18 (0.7%), and in the nipple-areolar complex in 9 (0.4%). After implant reconstruction (n=1,917), local recurrences sites included the skin in 91 (4.7%) patients, chest wall in 8 (0.4%), and nipple-areolar complex in 8 (0.4%). Of the 70 lesions with reported in-breast location, 57 (81.4%) relapsed in the original tumor location. Discussion: Although meta-analysis was not conducted, present analysis demonstrated that most local recurrences after skin-sparing or nipple-sparing mastectomy occurred within the skin or subcutaneous tissues. It was found that the original tumor location was the most frequent site of relapse. Therefore, special attention should be paid to the original tumor overlying the skin while planning postmastectomy radiation therapy.

Original languageEnglish
Pages (from-to)2037-2046
Number of pages10
JournalGland Surgery
Volume10
Issue number6
DOIs
StatePublished - 2021

Keywords

  • Breast neoplasm
  • breast implants
  • breast reconstruction
  • mastectomy

Fingerprint

Dive into the research topics of 'Pattern of local recurrence after mastectomy and reconstruction in breast cancer patients: A systematic review'. Together they form a unique fingerprint.

Cite this