Peptide-based targeted therapeutics and apoptosis imaging probes for cancer therapy

Sri Murugan Poongkavithai Vadevoo; Smriti Gurung; Fatima Khan; Md Enamul Haque; Gowri Rangaswamy Gunassekaran; Lianhua Chi; Uttapol Permpoon; Byungheon Lee

doi:10.1007/s12272-019-01125-0

Peptide-based targeted therapeutics and apoptosis imaging probes for cancer therapy

Sri Murugan Poongkavithai Vadevoo, Smriti Gurung, Fatima Khan, Md Enamul Haque, Gowri Rangaswamy Gunassekaran, Lianhua Chi, Uttapol Permpoon, Byungheon Lee

Kyungpook National University

Research output: Contribution to journal › Review article › peer-review

29 Scopus citations

Abstract

Peptides have advantages over antibodies in terms of deep tissue penetration, low immunogenicity, and cost-effective production, but they have short circulation time and poor stability in vivo. Peptides have been extensively used as targeting moieties for the delivery of drug-loaded nanoparticles and function as targeted therapeutics in cancer treatment. Here, we review peptides that are exploited as targeted therapeutics in cancer therapy and apoptosis imaging probes for the monitoring of treatment responses.

Original language	English
Pages (from-to)	150-158
Number of pages	9
Journal	Archives of Pharmacal Research
Volume	42
Issue number	2
DOIs	https://doi.org/10.1007/s12272-019-01125-0
State	Published - 4 Feb 2019

Keywords

Apoptosis
CD44v6
Imaging
PD-L1
Phage display
Pro-apoptotic peptide
Targeted therapeutics

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s12272-019-01125-0

Cite this

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abstract = "Peptides have advantages over antibodies in terms of deep tissue penetration, low immunogenicity, and cost-effective production, but they have short circulation time and poor stability in vivo. Peptides have been extensively used as targeting moieties for the delivery of drug-loaded nanoparticles and function as targeted therapeutics in cancer treatment. Here, we review peptides that are exploited as targeted therapeutics in cancer therapy and apoptosis imaging probes for the monitoring of treatment responses.",

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AU - Vadevoo, Sri Murugan Poongkavithai

AU - Gurung, Smriti

AU - Khan, Fatima

AU - Haque, Md Enamul

AU - Gunassekaran, Gowri Rangaswamy

AU - Chi, Lianhua

AU - Permpoon, Uttapol

AU - Lee, Byungheon

PY - 2019/2/4

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AB - Peptides have advantages over antibodies in terms of deep tissue penetration, low immunogenicity, and cost-effective production, but they have short circulation time and poor stability in vivo. Peptides have been extensively used as targeting moieties for the delivery of drug-loaded nanoparticles and function as targeted therapeutics in cancer treatment. Here, we review peptides that are exploited as targeted therapeutics in cancer therapy and apoptosis imaging probes for the monitoring of treatment responses.

KW - Apoptosis

KW - CD44v6

KW - Imaging

KW - PD-L1

KW - Phage display

KW - Pro-apoptotic peptide

KW - Targeted therapeutics

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JF - Archives of Pharmacal Research

IS - 2

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Peptide-based targeted therapeutics and apoptosis imaging probes for cancer therapy

Abstract

Keywords

UN SDGs

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