TY - JOUR
T1 - Peptides as multifunctional players in cancer therapy
AU - Vadevoo, Sri Murugan Poongkavithai
AU - Gurung, Smriti
AU - Lee, Hyun Su
AU - Gunassekaran, Gowri Rangaswamy
AU - Lee, Seok Min
AU - Yoon, Jae Won
AU - Lee, Yun Ki
AU - Lee, Byungheon
N1 - Publisher Copyright:
© 2023, The Author(s).
PY - 2023/6
Y1 - 2023/6
N2 - Peptides exhibit lower affinity and a shorter half-life in the body than antibodies. Conversely, peptides demonstrate higher efficiency in tissue penetration and cell internalization than antibodies. Regardless of the pros and cons of peptides, they have been used as tumor-homing ligands for delivering carriers (such as nanoparticles, extracellular vesicles, and cells) and cargoes (such as cytotoxic peptides and radioisotopes) to tumors. Additionally, tumor-homing peptides have been conjugated with cargoes such as small-molecule or chemotherapeutic drugs via linkers to synthesize peptide–drug conjugates. In addition, peptides selectively bind to cell surface receptors and proteins, such as immune checkpoints, receptor kinases, and hormone receptors, subsequently blocking their biological activity or serving as hormone analogs. Furthermore, peptides internalized into cells bind to intracellular proteins and interfere with protein–protein interactions. Thus, peptides demonstrate great application potential as multifunctional players in cancer therapy.
AB - Peptides exhibit lower affinity and a shorter half-life in the body than antibodies. Conversely, peptides demonstrate higher efficiency in tissue penetration and cell internalization than antibodies. Regardless of the pros and cons of peptides, they have been used as tumor-homing ligands for delivering carriers (such as nanoparticles, extracellular vesicles, and cells) and cargoes (such as cytotoxic peptides and radioisotopes) to tumors. Additionally, tumor-homing peptides have been conjugated with cargoes such as small-molecule or chemotherapeutic drugs via linkers to synthesize peptide–drug conjugates. In addition, peptides selectively bind to cell surface receptors and proteins, such as immune checkpoints, receptor kinases, and hormone receptors, subsequently blocking their biological activity or serving as hormone analogs. Furthermore, peptides internalized into cells bind to intracellular proteins and interfere with protein–protein interactions. Thus, peptides demonstrate great application potential as multifunctional players in cancer therapy.
UR - http://www.scopus.com/inward/record.url?scp=85160731218&partnerID=8YFLogxK
U2 - 10.1038/s12276-023-01016-x
DO - 10.1038/s12276-023-01016-x
M3 - Review article
C2 - 37258584
AN - SCOPUS:85160731218
SN - 1226-3613
VL - 55
SP - 1099
EP - 1109
JO - Experimental and Molecular Medicine
JF - Experimental and Molecular Medicine
IS - 6
ER -