Persicarin isolated from Oenanthe javanica protects against diabetes-induced oxidative stress and inflammation in the liver of streptozotocin-induced type 1 diabetic mice

Persicarin is one of the major components of the Oenanthe javanica (water dropwort). The present study was aimed to evaluate the role of persicarin in the hepatic tissue of streptozotocin-induced type 1 diabetic mice. Diabetes was induced by single intra-peritoneal injection of streptozotocin (120 mg/kg body weight) and then oral administration of persicarin at a dose 2.5 and 5 mg/kg body weight for 10 days. Serum and hepatic glucose levels were increased in diabetic control mice, while persicarin treatment groups were markedly reduced. Also, the increased levels of ALT and AST in serum were improved by persicarin. In our results revealed that persicarin suppressed increased oxidative stress parameter (reactive oxygen species, peroxinitrite, and thiobarbituric acid-reactive substance), nicotinamide adenine dinucleotide phosphate oxidase subunit (Nox-4 and P47^phox) and inflammatory related makers (NF-_κB, AP-1, TGF-_β, COX-2, and iNOS). These results suggest that persicarin protects against liver damage by attenuating oxidative stress and inflammatory response under hyperglycemic conditions. Thus, persicarin could perform as a potential therapeutic agent for the treatment of diabetic mellitus.