Persistent organic pollutants and promoter hypermethylation of the O-methylguanine-DNA methyltransferase gene

Soo Yeun Park; Ki Su Kim; Yu Mi Lee; Mi Jin Kim; David R. Jacobs; Miquel Porta; Dong Sun Kim; Duk Hee Lee

doi:10.3109/1354750X.2014.1002806

Persistent organic pollutants and promoter hypermethylation of the O-methylguanine-DNA methyltransferase gene

Soo Yeun Park, Ki Su Kim, Yu Mi Lee, Mi Jin Kim, David R. Jacobs, Miquel Porta, Dong Sun Kim, Duk Hee Lee

Department of Medicine

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

Promoter hypermethylation of the O-methylguanine-DNA methyltransferase (MGMT) DNA repair gene is important during carcinogenesis. We explored whether organochlorine pesticides (OCPs) and polychlorinated biphenyls (PCBs), were associated with hypermethylation of the MGMT gene promoter in peripheral leukocytes among 368 Koreans without cancer. Hypermethylation decreased as OCPs increased (Ptrend=0.02), while PCB concentrations showed an inverted U-shaped association (Pquadratic<0.01). The prevalence of MGMT promoter hypermethylation was highest within the 2nd quintile of the PCB summary score (28.4%), while it was only 2.7% in the upper 10% score. Chronic exposure to these chemicals may affect methylation of the MGMT promoter, with possibly non-monotonic dose response relationships.

Original language	English
Pages (from-to)	136-142
Number of pages	7
Journal	Biomarkers
Volume	20
Issue number	2
DOIs	https://doi.org/10.3109/1354750X.2014.1002806
State	Published - 1 Mar 2015

Keywords

Methylation
MGMT
Organochlorine pesticides
Persistent organic pollutants
Polychlorinated biphenyls

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3109/1354750X.2014.1002806

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title = "Persistent organic pollutants and promoter hypermethylation of the O-methylguanine-DNA methyltransferase gene",

abstract = "Promoter hypermethylation of the O-methylguanine-DNA methyltransferase (MGMT) DNA repair gene is important during carcinogenesis. We explored whether organochlorine pesticides (OCPs) and polychlorinated biphenyls (PCBs), were associated with hypermethylation of the MGMT gene promoter in peripheral leukocytes among 368 Koreans without cancer. Hypermethylation decreased as OCPs increased (Ptrend=0.02), while PCB concentrations showed an inverted U-shaped association (Pquadratic<0.01). The prevalence of MGMT promoter hypermethylation was highest within the 2nd quintile of the PCB summary score (28.4%), while it was only 2.7% in the upper 10% score. Chronic exposure to these chemicals may affect methylation of the MGMT promoter, with possibly non-monotonic dose response relationships.",

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author = "Park, {Soo Yeun} and Kim, {Ki Su} and Lee, {Yu Mi} and Kim, {Mi Jin} and Jacobs, {David R.} and Miquel Porta and Kim, {Dong Sun} and Lee, {Duk Hee}",

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doi = "10.3109/1354750X.2014.1002806",

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AU - Park, Soo Yeun

AU - Kim, Ki Su

AU - Lee, Yu Mi

AU - Kim, Mi Jin

AU - Jacobs, David R.

AU - Porta, Miquel

AU - Kim, Dong Sun

AU - Lee, Duk Hee

PY - 2015/3/1

Y1 - 2015/3/1

N2 - Promoter hypermethylation of the O-methylguanine-DNA methyltransferase (MGMT) DNA repair gene is important during carcinogenesis. We explored whether organochlorine pesticides (OCPs) and polychlorinated biphenyls (PCBs), were associated with hypermethylation of the MGMT gene promoter in peripheral leukocytes among 368 Koreans without cancer. Hypermethylation decreased as OCPs increased (Ptrend=0.02), while PCB concentrations showed an inverted U-shaped association (Pquadratic<0.01). The prevalence of MGMT promoter hypermethylation was highest within the 2nd quintile of the PCB summary score (28.4%), while it was only 2.7% in the upper 10% score. Chronic exposure to these chemicals may affect methylation of the MGMT promoter, with possibly non-monotonic dose response relationships.

AB - Promoter hypermethylation of the O-methylguanine-DNA methyltransferase (MGMT) DNA repair gene is important during carcinogenesis. We explored whether organochlorine pesticides (OCPs) and polychlorinated biphenyls (PCBs), were associated with hypermethylation of the MGMT gene promoter in peripheral leukocytes among 368 Koreans without cancer. Hypermethylation decreased as OCPs increased (Ptrend=0.02), while PCB concentrations showed an inverted U-shaped association (Pquadratic<0.01). The prevalence of MGMT promoter hypermethylation was highest within the 2nd quintile of the PCB summary score (28.4%), while it was only 2.7% in the upper 10% score. Chronic exposure to these chemicals may affect methylation of the MGMT promoter, with possibly non-monotonic dose response relationships.

KW - Methylation

KW - MGMT

KW - Organochlorine pesticides

KW - Persistent organic pollutants

KW - Polychlorinated biphenyls

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Persistent organic pollutants and promoter hypermethylation of the O-methylguanine-DNA methyltransferase gene

Abstract

Keywords

UN SDGs

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